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儿童涎石病的组织病理学和超微结构研究结果:简要通讯

Histopathology and ultrastructural findings of pediatric sialolithiasis: a brief communication.

作者信息

Mustakim Kezia Rachellea, Nguyen Truc Thi Hoang, Eo Mi Young, Kim Soung Min

机构信息

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.

出版信息

J Korean Assoc Oral Maxillofac Surg. 2022 Apr 30;48(2):125-129. doi: 10.5125/jkaoms.2022.48.2.125.

DOI:10.5125/jkaoms.2022.48.2.125
PMID:35491145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9065641/
Abstract

Sialolithiasis is a condition in which the salivary gland excretory duct is obstructed due to the formation of calcareous deposits and is uncommon in children compared to adults. The treatment modalities range from a conservative approach involving hydration to a surgical approach. Though several studies have analyzed the sialolith micromorphology structures, studies on pediatric sialoliths remain scarce. This brief communication aims to describe the sialolith micromorphology to understand the mechanism of mineralization and growth of pediatric sialoliths. A 6-year-old Korean female presented with swelling under her tongue. The intraoral examination revealed a painless yellowish hard mass beneath the tongue near the Wharton's duct which was suspected as a sialolith. After receiving the informed consent, the sialolithotomy was performed under local anesthesia. The obtained stone was analyzed through histopathology and transmission electron microscope examinations to understand the mechanism of mineralization and growth of pediatric sialolith. The micromorphology and growth processes of pediatric sialolith remain undescribed. More comprehensive microscopic studies are needed regarding their distinctive characteristics. By expanding knowledge about sialoliths micromorphology, development of new preventive, diagnostic and patient-tailored treatment methods of pediatric sialolithiasis will be enhanced.

摘要

涎石病是一种由于钙质沉积物形成而导致唾液腺排泄管阻塞的疾病,与成人相比在儿童中并不常见。治疗方式从包括补水的保守方法到手术方法不等。尽管有几项研究分析了涎石的微观形态结构,但关于儿童涎石的研究仍然很少。这篇简短的通讯旨在描述涎石的微观形态,以了解儿童涎石矿化和生长的机制。一名6岁韩国女性因舌下肿胀就诊。口腔检查发现舌下靠近颌下腺导管处有一个无痛的淡黄色硬块,怀疑是涎石。在获得知情同意后,在局部麻醉下进行了涎石切除术。对取出的结石进行了组织病理学和透射电子显微镜检查,以了解儿童涎石矿化和生长的机制。儿童涎石的微观形态和生长过程仍未得到描述。需要对其独特特征进行更全面的微观研究。通过扩展对涎石微观形态的认识,将加强儿童涎石病新的预防、诊断和针对患者的治疗方法的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/0230044e5aac/jkaoms-48-2-125-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/2478993f6803/jkaoms-48-2-125-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/902f9bed53b4/jkaoms-48-2-125-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/0230044e5aac/jkaoms-48-2-125-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/2478993f6803/jkaoms-48-2-125-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/902f9bed53b4/jkaoms-48-2-125-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e717/9065641/0230044e5aac/jkaoms-48-2-125-f3.jpg

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Identification of biological components for sialolith formation organized in circular multi-layers.鉴定以环状多层形式排列的涎石形成的生物组成成分。
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本文引用的文献

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Recurrent Submandibular Sialolithiasis in a Child.一名儿童复发性下颌下涎石病
Cureus. 2020 Dec 19;12(12):e12163. doi: 10.7759/cureus.12163.
2
Classification of submandibular salivary stones based on ultrastructural studies.基于超微结构研究的下颌下腺唾液结石分类。
Oral Dis. 2021 Oct;27(7):1711-1719. doi: 10.1111/odi.13708. Epub 2020 Nov 28.
3
A comprehensive analysis of sialolith proteins and the clinical implications.涎石蛋白的综合分析及其临床意义。
Clin Proteomics. 2020 Mar 31;17:12. doi: 10.1186/s12014-020-09275-w. eCollection 2020.
4
Characterization of a submandibular gland sialolith: micromorphology, crystalline structure, and chemical compositions.下颌下腺涎石的特征:微观形态、晶体结构和化学成分。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jul;124(1):e13-e20. doi: 10.1016/j.oooo.2017.03.011. Epub 2017 Mar 20.
5
Pediatric sialadenitis.小儿涎腺炎
Otolaryngol Clin North Am. 2014 Oct;47(5):763-78. doi: 10.1016/j.otc.2014.06.009. Epub 2014 Aug 13.
6
Structure and growth of sialoliths: computed microtomography and electron microscopy investigation of 30 specimens.涎石的结构和生长:30 例标本的计算微断层扫描和电子显微镜研究。
Microsc Microanal. 2013 Oct;19(5):1190-203. doi: 10.1017/S1431927613001694. Epub 2013 Sep 4.
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8
Micromorphology of sialoliths in submandibular salivary gland: a scanning electron microscope and X-ray diffraction analysis.下颌下唾液腺涎石的微观形态:扫描电子显微镜及X射线衍射分析
J Oral Maxillofac Surg. 2004 Oct;62(10):1253-8. doi: 10.1016/j.joms.2003.11.018.
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Sialolithiasis in children as a diagnostic dilemma.儿童涎石病作为一种诊断难题。
Eur Arch Otorhinolaryngol. 2000;257(3):161-3. doi: 10.1007/s004050050215.