Im Yeong-Gwan, Kook Min-Suk, Kim Byung-Gook, Kim Jae-Hyung, Park Yeong-Joon, Song Ho-Jun
Department of Oral Medicine, Chonnam National University Dental Hospital, Gwangju, Republic of Korea.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jul;124(1):e13-e20. doi: 10.1016/j.oooo.2017.03.011. Epub 2017 Mar 20.
The aim of this study was to understand the mechanism of mineralization and growth of a sialolith by analyzing its micromorphology, crystalline structure, and chemical compositions.
A sialolith was removed along with submandibular salivary gland from a patient. After cross-cutting and polishing the sialolith, its morphology, chemical compositions, crystalline structure, and chemical states were analyzed by using optical camera, scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffractometer, Fourier transform infrared spectrophotometer, and transmittance electron microscopy.
The sialolith had a core composed of organic material, such as lipid compounds, and the surrounding mineralized shell structure mostly consisted of hydroxyapatite. In the transition zone between the organic core and mineralized shell layers, inorganic layers were arranged alternately with organic layers. Congregated globular structures were calcified with hydroxyapatite and whitlockite crystallites. Analysis of crystalline structures and chemical compositions suggested that calcium phosphate minerals containing magnesium, such as whitlockite, were developed in the initial stage and gradually transformed into crystallites composed of hydroxyapatite during the growth of crystallites.
Sialolith with an organic core grew as inorganic materials were deposited and calcified in alternate layers. The mineralization process might include the initial whitlockite development and successive transformation into more stable hydroxyapatite.
本研究旨在通过分析涎石的微观形态、晶体结构和化学成分，了解涎石矿化和生长的机制。
从一名患者身上切除涎石及下颌下唾液腺。对涎石进行横切和抛光后，使用光学相机、扫描电子显微镜、能量色散X射线光谱仪、X射线衍射仪、傅里叶变换红外光谱仪和透射电子显微镜分析其形态、化学成分、晶体结构和化学状态。
涎石有一个由脂质化合物等有机物质组成的核心，周围的矿化壳结构主要由羟基磷灰石组成。在有机核心层和矿化壳层之间的过渡区域，无机层与有机层交替排列。聚集的球状结构被羟基磷灰石和白磷钙矿微晶钙化。晶体结构和化学成分分析表明，含镁的磷酸钙矿物，如白磷钙矿，在微晶生长初期形成，并在微晶生长过程中逐渐转变为由羟基磷灰石组成的微晶。
具有有机核心的涎石随着无机材料交替沉积和钙化而生长。矿化过程可能包括最初白磷钙矿的形成以及随后向更稳定的羟基磷灰石的转变。
