Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA..
Trends Cell Biol. 2022 Sep;32(9):773-785. doi: 10.1016/j.tcb.2022.03.010. Epub 2022 Apr 29.
Cell-cycle progression and division are fundamental biological processes in animal cells, and their biochemical regulation has been extensively studied. An emerging body of work has revealed how mechanical interactions of cells with their microenvironment in tissues, including with the extracellular matrix (ECM) and neighboring cells, also plays a crucial role in regulating cell-cycle progression and division. We review recent work on how cells interpret physical cues and alter their mechanics to promote cell-cycle progression and initiate cell division, and then on how dividing cells generate forces on their surrounding microenvironment to successfully divide. Finally, the article ends by discussing how force generation during division potentially contributes to larger tissue-scale processes involved in development and homeostasis.
细胞周期的进展和分裂是动物细胞的基本生物学过程，其生化调节已得到广泛研究。越来越多的研究揭示了细胞与组织中的微环境（包括细胞外基质 (ECM) 和相邻细胞）的机械相互作用如何在调节细胞周期的进展和分裂中发挥关键作用。我们回顾了最近的研究工作，探讨了细胞如何解释物理线索并改变其力学特性以促进细胞周期的进展和启动细胞分裂，以及正在分裂的细胞如何在其周围微环境中产生力以成功分裂。最后，文章讨论了在分裂过程中产生力如何有助于涉及发育和动态平衡的更大的组织尺度过程。
