斑秃的免疫发病机制。
Immunopathogenesis of alopecia areata.
作者信息
Olayinka Jadesola Jadé Temitope, Richmond Jillian M
机构信息
College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Department of Dermatology, UMass Medical School, Worcester, MA, USA.
出版信息
Curr Res Immunol. 2021 Feb 6;2:7-11. doi: 10.1016/j.crimmu.2021.02.001. eCollection 2021.
Abstract
Alopecia areata (AA) is an autoimmune disorder resulting in hair loss. It has numerous variants or patterns, including diffuse type, patchy type, AA totalis, AA universalis, and more. In this graphical review, we provide an overview of AA immunopathogenesis, highlighting loss of immune privilege in the hair follicle as well as key immune cell types, cytokines and chemokines that drive autoimmune attack of the hair follicle. We also summarize recent literature identifying agents that block these pathways that could serve as new immunomodulatory treatments for AA.
摘要
斑秃（AA）是一种导致脱发的自身免疫性疾病。它有许多变体或模式，包括弥漫型、斑片状、全秃、普秃等等。在这篇图文综述中，我们概述了斑秃的免疫发病机制，强调毛囊免疫特权的丧失以及驱动毛囊自身免疫攻击的关键免疫细胞类型、细胞因子和趋化因子。我们还总结了最近的文献，这些文献确定了阻断这些途径的药物，这些药物可作为斑秃的新型免疫调节治疗方法。
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本文引用的文献
1
A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States.
Clin Cosmet Investig Dermatol. 2020 Apr 1;13:259-266. doi: 10.2147/CCID.S245649. eCollection 2020.
2
Serum Interleukin-15 is a Marker of Alopecia Areata Severity.
Int J Trichology. 2019 Jan-Feb;11(1):26-30. doi: 10.4103/ijt.ijt_80_18.
3
High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata.
JCI Insight. 2018 Oct 4;3(19):121949. doi: 10.1172/jci.insight.121949.
4
Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.
Sci Transl Med. 2018 Jul 18;10(450). doi: 10.1126/scitranslmed.aam7710.
5
Alopecia areata.
Nat Rev Dis Primers. 2017 Mar 16;3:17011. doi: 10.1038/nrdp.2017.11.
6
Bone marrow-derived mesenchymal stem cells prevent alopecia areata development through the inhibition of NKG2D expression: A pilot study.
Exp Dermatol. 2017 Jun;26(6):532-535. doi: 10.1111/exd.13255.
7
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.
JCI Insight. 2016 Sep 22;1(15):e89776. doi: 10.1172/jci.insight.89776.
8
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata.
J Immunol. 2016 Aug 15;197(4):1089-99. doi: 10.4049/jimmunol.1501798. Epub 2016 Jul 13.
9
Molecular signatures define alopecia areata subtypes and transcriptional biomarkers.
EBioMedicine. 2016 May;7:240-7. doi: 10.1016/j.ebiom.2016.03.036. Epub 2016 Mar 31.
10
Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata.
J Invest Dermatol. 2016 Jan;136(1):314-317. doi: 10.1038/JID.2015.402.
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