蛋白质和核酸的非酶糖基化、其在糖尿病并发症发展中的重要性、衰老的可能分子基础及自身免疫过程。
The nonenzymatic glycation of proteins and nucleic acids, their importance for the development of diabetic complications, possible molecular basis of aging and autoimmunological processes.
作者信息
Krantz S, Lober M, Henschel L
出版信息
Exp Clin Endocrinol. 1986 Dec;88(3):257-69. doi: 10.1055/s-0029-1210605.
PMID:3549330
Abstract
The formation of nonenzymatic glycation products of proteins and nucleic acids appears to be a link between chronic hyperglycaemia and long-term diabetic complications and special forms of aging during normoglycaemia. The major effects of extended glycation include cross-linking of glycated proteins, attachment of soluble proteins to extracellular glycated matrices, conformational changes of proteins followed by altered functions and immunogenicity, and abnormalities in nucleic acid functions.
摘要
蛋白质和核酸的非酶糖基化产物的形成似乎是慢性高血糖与长期糖尿病并发症以及正常血糖水平下特殊形式衰老之间的一个联系。长期糖基化的主要影响包括糖化蛋白质的交联、可溶性蛋白质与细胞外糖化基质的附着、蛋白质的构象变化进而导致功能和免疫原性改变，以及核酸功能异常。
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