Brownlee M
Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Clin Invest Med. 1995 Aug;18(4):275-81.
Hyperglycemia, the most obvious metabolic abnormality in diabetes, is the primary casual factor responsible for the development of diabetic microvascular complications. There is considerable evidence linking hyperglycemia with the accelerated formation of irreversible nonenzymatic advanced glycosylation end products (AGEs), which subsequently accumulate in vessel wall proteins. The development of long-term vascular complications associated with diabetes appears to be related to the accumulation of these AGEs. Compounds that inhibit the development of AGE formation prevent complications in animal models and, therefore, may prove useful in reducing chronic diabetes-related complications in patients.
高血糖是糖尿病最明显的代谢异常，是导致糖尿病微血管并发症的主要原因。有大量证据表明，高血糖与不可逆的非酶促晚期糖基化终产物（AGEs）加速形成有关，这些产物随后会在血管壁蛋白中积累。与糖尿病相关的长期血管并发症的发生似乎与这些AGEs的积累有关。在动物模型中，抑制AGE形成的化合物可预防并发症，因此可能对减少患者慢性糖尿病相关并发症有用。
