GENYO: Centro Pfizer, Universidad de Granada, Junta de Andalucía de Genómica e Investigación Oncológica, Granada, Spain.
Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México "Dr. Federico Gomez", Ciudad de México, Mexico.
Front Immunol. 2022 Apr 14;13:803995. doi: 10.3389/fimmu.2022.803995. eCollection 2022.
In 1975 two independent groups noticed the presence of immune cells with a unique ability to recognize and eliminate transformed hematopoietic cells without any prior sensitization or expansion of specific clones. Since then, NK cells have been the axis of thousands of studies that have resulted until June 2021, in more than 70 000 publications indexed in PubMed. As result of this work, which include approaches , , and , it has been possible to appreciate the role played by the NK cells, not only as effectors against specific pathogens, but also as regulators of the immune response. Recent advances have revealed previous unidentified attributes of NK cells including the ability to adapt to new conditions under the context of chronic infections, or their ability to develop some memory-like characteristics. In this review, we will discuss significant findings that have rule our understanding of the NK cell biology, the developing of these findings into new concepts in immunology, and how these conceptual platforms are being used in the design of strategies for cancer immunotherapy.
1975 年，两个独立的研究小组注意到，免疫细胞具有一种独特的能力，可以识别和消除转化的造血细胞，而无需事先致敏或特异性克隆的扩增。从那时起，NK 细胞已经成为数千项研究的核心，这些研究的成果截至 2021 年 6 月，在 PubMed 中索引了超过 70000 篇出版物。作为这项工作的结果，包括方法、和，已经有可能认识到 NK 细胞所扮演的角色，不仅作为针对特定病原体的效应物，而且作为免疫反应的调节剂。最近的进展揭示了 NK 细胞以前未被识别的属性，包括在慢性感染的情况下适应新条件的能力，或它们发展出一些类似记忆的特征的能力。在这篇综述中，我们将讨论重要的发现，这些发现改变了我们对 NK 细胞生物学的理解，将这些发现发展成免疫学中的新概念，以及这些概念平台如何被用于设计癌症免疫治疗的策略。
