2020年哥伦比亚佩雷拉市针对特定媒介传播病原体的犬类血清流行率调查及其与贫困的关系
Seroprevalence canine survey for selected vector-borne pathogens and its relationship with poverty in metropolitan Pereira, Colombia, 2020.
作者信息
Bonilla-Aldana D Katterine, Gutiérrez-Grajales Erwin J, Martínez-Arboleda J Paola, Reina-Mora María Angelica, Trejos-Mendoza Adrián E, Pérez-Vargas Soffia, Valencia-Mejía Lorenzo, Marín-Arboleda Luisa F, Osorio-Navia Daniela, Chacón-Peña Mariana, González-Colonia Luz Victoria, Cardona-Ospina Jaime A, Jiménez-Posada Erika Vanessa, Diaz Andrés, Salazar Jean Carlos, Sierra Manuel, Muñoz-Lara Fausto, Zambrano Lysien I, Ramírez-Vallejo Eduardo, Álvarez Juan Camilo, Jaramillo-Delgado Ingrid Lorena, Pecho-Silva Samuel, Paniz-Mondolfi Alberto, Faccini-Martínez Álvaro A, Rodríguez-Morales Alfonso J
机构信息
Semillero de Investigación en Zoonosis (SIZOO), Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia.
Institución Universitaria Visión de las Américas, Pereira, Risaralda, Colombia.
出版信息
Parasite Epidemiol Control. 2022 Apr 1;17:e00249. doi: 10.1016/j.parepi.2022.e00249. eCollection 2022 May.
BACKGROUND
Tick-borne diseases (TBD) and dirofilariosis are currently not under surveillance in most Latin American countries. In addition, there is a significant lack of studies describing the current situation in most endemic areas, including Colombia. Therefore, seroprevalence studies are crucial for understanding the epidemiology of these vector-borne diseases.
METHODS
A serosurvey for TBD and dirofilariosis among 100 dogs was carried out in the municipality of Pereira, located in the Coffee-Triangle region, Colombia. Samples were tested using a rapid assay test system (SNAP® 4Dx®); based on an enzyme immunoassay technique' screening for antibodies to (sensitivity 99.1%)' s.l. (98.8%), and (96.2%) by using specific antigens and checking for antigen based on specific antibodies (99.2%). Bivariate analyses were performed on Stata®14, significant < 0.05.
FINDINGS
Global seroprevalence to the selected vector-borne pathogens was 74% (95%CI 65-83%). The highest seroprevalence was found for (74%), followed by (16%). Seropositivity for spp. and spp. was 0%. All spp. seropositive dogs showed co-detection of spp. (16%). Seroprevalence was significantly higher among dogs from families of lower socioeconomic status/level (I, 86%), followed by level II (74%), and III (36%) ( = 0.001). All dogs exhibiting anorexia (12%) were invariably seropositive (100%) ( = 0.029). Seroprevalence was higher among those showing mucocutaneous paleness (95%) compared to those without paleness (68%) ( = 0.013) (OR = 9.3; 95%CI 1.18-72.9). There was high variability in seroprevalence through the studied areas, ranging from 0% (La Libertad Park) up to Combia, Cesar Nader, Las Brisas and Saturno localities (100%) ( = 0.033).
INTERPRETATION
Given the high seroprevalence obtained in an area with documented ticks, there is a potential risk of zoonotic transmission to humans. Further seroprevalence studies in humans are needed to assess the prevalence of infections. Poverty is highly associated with these tick-borne pathogens in Pereira, as shown in the present study.
背景
在大多数拉丁美洲国家，蜱传疾病（TBD）和恶丝虫病目前未受到监测。此外，在包括哥伦比亚在内的大多数流行地区，严重缺乏描述当前状况的研究。因此，血清阳性率研究对于了解这些媒介传播疾病的流行病学至关重要。
方法
在哥伦比亚咖啡三角地区的佩雷拉市，对100只狗进行了TBD和恶丝虫病的血清学调查。样本使用快速检测系统（SNAP® 4Dx®）进行检测；基于酶免疫测定技术，通过使用特异性抗原筛选针对犬埃立克体（敏感性99.1%）、犬巴贝斯虫（98.8%）和犬心丝虫（96.2%）的抗体，并根据特异性抗体检测犬心丝虫抗原（99.2%）。在Stata®14上进行双变量分析，显著性P<0.05。
结果
对选定的媒介传播病原体的总体血清阳性率为74%（95%可信区间65 - 83%）。犬埃立克体的血清阳性率最高（74%），其次是犬巴贝斯虫（16%）。犬无形体属和犬泰勒虫属的血清阳性率为0%。所有犬埃立克体血清阳性的狗均显示同时检测到犬巴贝斯虫（16%）。社会经济地位/水平较低家庭的狗的血清阳性率显著更高（I级，86%），其次是II级（74%）和III级（36%）（P = 0.001）。所有表现出厌食的狗（12%）均为血清阳性（100%）（P = 0.029）。与无皮肤黏膜苍白的狗相比，有皮肤黏膜苍白的狗血清阳性率更高（95%）（P = 0.013）（比值比 = 9.3；95%可信区间1.18 - 72.9）。在所研究地区，血清阳性率差异很大，从0%（拉利伯塔德公园）到孔比亚、塞萨尔·纳德尔、拉斯布里萨斯和土星地区（100%）（P = 0.033）。
解读
鉴于在有蜱记录的地区获得了较高的血清阳性率，存在人畜共患病传播给人类的潜在风险。需要对人类进行进一步的血清阳性率研究，以评估感染的流行情况。如本研究所示，在佩雷拉，贫困与这些蜱传病原体高度相关。
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