Ma Mingwei, Li Jie, Zhang Zimu, Sun Juan, Liu Zhen, Zeng Ziyang, Ouyang Siwen, Kang Weiming
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of General Surgery, Peking Union Medical College Hospital, Beijing, China.
Front Oncol. 2022 Apr 14;12:858892. doi: 10.3389/fonc.2022.858892. eCollection 2022.
microRNAs (miRNAs) are a type of small endogenous non-coding RNAs composed of 20-22 nucleotides, which can regulate the expression of a gene by targeting 3' untranslated region (3'-UTR) of mRNA. Many studies have reported that miRNAs are involved in the occurrence and progression of human diseases, including malignant tumors. miR-1224 plays significant roles in different tumors, including tumor proliferation, metastasis, invasion, angiogenesis, biological metabolism, and drug resistance. Mostly, it serves as a tumor suppressor. With accumulating proofs of miR-1224, it can act as a potential bio-indicator in the diagnosis and prognosis of patients with cancer. In this article, we review the characteristics and research progress of miR-1224 and emphasize the regulation and function of miR-1224 in different cancer. Furthermore, we conclude the clinical implications of miR-1224. This review may provide new horizons for deeply understanding the role of miR-1224 as biomarkers and therapeutic targets in human cancer.
微小RNA（miRNA）是一类由20-22个核苷酸组成的内源性非编码小RNA，其可通过靶向mRNA的3'非翻译区（3'-UTR）来调控基因表达。许多研究报道，miRNA参与包括恶性肿瘤在内的人类疾病的发生和发展。miR-1224在不同肿瘤中发挥重要作用，包括肿瘤增殖、转移、侵袭、血管生成、生物代谢及耐药性。多数情况下，它起肿瘤抑制作用。随着miR-1224证据的不断积累，它可作为癌症患者诊断和预后的潜在生物指标。在本文中，我们综述了miR-1224的特性和研究进展，并着重阐述了miR-1224在不同癌症中的调控及功能。此外，我们总结了miR-1224的临床意义。本综述可能为深入理解miR-1224作为人类癌症生物标志物和治疗靶点的作用提供新视野。
