Li Jie, Zhang Zhiyuan, Chen Fangyu, Hu Tao, Peng Wen, Gu Qiou, Sun Yueming
First Clinical Medical College, Nanjing Medical University, Nanjing, China.
Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Oncol. 2019 Jun 20;9:518. doi: 10.3389/fonc.2019.00518. eCollection 2019.
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate gene expression at the post-transcriptional/translational level. They act a considerable role not only in the normal progress of development but also in aberrant human diseases, including malignancy. With accumulating proofs of miR-105, the complex role of miR-105 during cancer initiation and progression is gradually emerging. miR-105 acts as a tumor suppressor by inhibiting tumor growth and metastasis or as an oncogene by promoting tumor initiation and invasion, depending on particular tumor contexts and base-pairing genes. In this review, we emphasize the characteristics of miR-105 in cancer to elucidate various deadly tumors and discuss transcriptional regulations that may explain fluctuations in miR-105 expression. This review may provide new ideas for applying miR-105 as a diagnostic and prognostic biomarker.
微小RNA（miRNA）是一类非编码小RNA分子，它们在转录后/翻译水平调控基因表达。它们不仅在正常发育进程中发挥重要作用，而且在包括恶性肿瘤在内的异常人类疾病中也起着重要作用。随着越来越多关于miR-105的证据积累，miR-105在癌症发生和发展过程中的复杂作用正逐渐显现出来。根据特定的肿瘤背景和碱基配对基因，miR-105通过抑制肿瘤生长和转移发挥肿瘤抑制作用，或者通过促进肿瘤发生和侵袭发挥癌基因作用。在本综述中，我们着重阐述miR-105在癌症中的特征，以阐明各种致命肿瘤，并讨论可能解释miR-105表达波动的转录调控。本综述可能为将miR-105用作诊断和预后生物标志物提供新思路。
