Liu Zhiqiang, Hu Weiwei, Zhang Hanwen, Tao Hongmei, Lei Peng, Liu Jie, Yu Yali, Dong Qian, Gao Lei, Zhang Dongying
Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Apr 21;15:1217-1226. doi: 10.2147/DMSO.S356001. eCollection 2022.
Heart failure with preserved ejection fraction (HFpEF) is an intricacy heterogeneous syndrome. However, the association between EAT and arterial stiffness in HFpEF patients remains unknown.
A total of 102 patients were enrolled into the study, and brachial-ankle pulse-wave velocity (baPWV), epicardial adipose tissue (EAT) and body composition were assessed. Linear regression analysis was carried out to model the relationship between variables (especially EAT thickness) and baPWV.
The results showed that patients with the thicker EAT fat pad (≥3.55 mm) tended to have comorbidities of hypertension, coronary artery disease (CAD), diabetes and hyperlipidemia, also with a higher level of obesity, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC) and triglyceride (TG). The level of baPWV was higher in EAT ≥3.55 mm group than the other group. BaPWV was positively associated with EAT, age, heart rate, waist circumference, visceral fat area, systolic and diastolic blood pressure, CRP and FBG. After adjusting for EAT, age and visceral fat area, EAT thickness (β = 0.256, P = 0.009) and visceral fat area (β = 0.229, P = 0.036) significantly associated with baPWV.
The study assessed for the first time that the increased EAT thickness was closely related with baPWV in HFpEF patients, suggesting patients with the thicker EAT may be independently associated with arterial stiffness under the context of HFpEF.
射血分数保留的心力衰竭（HFpEF）是一种复杂的异质性综合征。然而，HFpEF患者的心外膜脂肪组织（EAT）与动脉僵硬度之间的关联尚不清楚。
共纳入102例患者，评估其臂踝脉搏波速度（baPWV）、心外膜脂肪组织（EAT）和身体成分。进行线性回归分析以建立变量（尤其是EAT厚度）与baPWV之间的关系模型。
结果显示，EAT脂肪垫较厚（≥3.55mm）的患者往往合并高血压、冠状动脉疾病（CAD）、糖尿病和高脂血症，同时肥胖程度、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）和甘油三酯（TG）水平也较高。EAT≥3.55mm组的baPWV水平高于另一组。BaPWV与EAT、年龄、心率、腰围、内脏脂肪面积、收缩压和舒张压、CRP及FBG呈正相关。在调整EAT、年龄和内脏脂肪面积后，EAT厚度（β = 0.256，P = 0.009）和内脏脂肪面积（β = 0.229，P = 0.036）与baPWV显著相关。
该研究首次评估了HFpEF患者中EAT厚度增加与baPWV密切相关，提示EAT较厚的患者在HFpEF背景下可能与动脉僵硬度独立相关。
