Li Ze, Wu Changliang, Liu Zhen, Li Zhenlu, Peng Xingang, Huang Jinjian, Ren Jianan, Wang Peige
Department of Emergency Surgery, The Affiliated Hospital of Qingdao University 16 Jiangsu Road Qingdao 266000 P. R. China
Lab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, Affiliated to Southeast University 305 East Zhongshan Road Nanjing 210002 P. R. China
RSC Adv. 2020 Jan 8;10(3):1331-1340. doi: 10.1039/c9ra10455k. eCollection 2020 Jan 7.
Prosthetic materials are widely used for temporary abdominal closure after open abdomen (OA), but local adhesion, erosion and fistula formation caused by current materials seriously affect the quality of life of patients. Recently, a three-dimensional porous network structure hydrogel has been used to simulate cell extracellular matrix that can support cell growth and tissue regeneration. In this study, we prepared an interpenetrating double-network hydrogel by photoinitiating glycidyl methacrylate-conjugated xanthan (XG) and 4-arm polyethylene glycol thiol (TPEG). This double-network hydrogel combined stiffness and deformation ability as well as forming property, which could coat polypropylene (PP) mesh to reduce friction to wound tissues. Moreover, this double-network hydrogel exhibited a denser porous structure that controlled drug release without initial outburst. When testing the hydrogel-coated growth factor-loaded PP mesh on a rat model of OA, it was found that this composite material could reduce inflammation and promote granulation tissue growth. Therefore, our design provides a new strategy of material-assisted wound protection of OA and shows potential clinical applications.
人工合成材料被广泛应用于开腹术后的临时腹壁关闭，但现有材料引起的局部粘连、侵蚀和瘘管形成严重影响患者生活质量。近年来，一种三维多孔网络结构水凝胶被用于模拟能够支持细胞生长和组织再生的细胞外基质。在本研究中，我们通过光引发甲基丙烯酸缩水甘油酯共轭黄原胶（XG）和四臂聚乙二醇硫醇（TPEG）制备了一种互穿双网络水凝胶。这种双网络水凝胶兼具硬度和变形能力以及成型性能，可包覆聚丙烯（PP）网片以减少对伤口组织的摩擦。此外，这种双网络水凝胶呈现出致密的多孔结构，能够控制药物释放且无初始突释。在开腹大鼠模型上测试水凝胶包覆的负载生长因子的PP网片时，发现这种复合材料能够减轻炎症并促进肉芽组织生长。因此，我们的设计为开腹手术的材料辅助伤口保护提供了一种新策略，并显示出潜在的临床应用价值。
