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纳米诊疗学:纳米传感器在糖尿病管理中的应用

Nanotheranostics: application of nanosensors in diabetes management.

作者信息

Pathak Kalyani, Saikia Riya, Sarma Himangshu, Pathak Manash Pratim, Das Ratna Jyoti, Gogoi Urvashee, Ahmad Mohammad Zaki, Das Aparoop, Wahab Basel A Abdel

机构信息

Department of Pharmaceutical Sciences, Faculty of Science & Engineering, Dibrugarh University, 784006 Dibrugarh, Assam India.

Sophisticated Analytical Instrument Facility (SAIF), Girijananda Chowdhury Institute of Pharmaceutical Science (GIPS), Girijananda ChowdhuryUniversity, Guwahati, Assam India.

出版信息

J Diabetes Metab Disord. 2023 Mar 17;22(1):119-133. doi: 10.1007/s40200-023-01206-4. eCollection 2023 Jun.

Abstract

OBJECTIVES

The objective of the present study is to discuss the use of nanomaterials like nanosensors for diagnosing Diabetes and highlight their applications in the treatment of Diabetes.

METHODS

Diabetes mellitus (D.M.) is a group of metabolic diseases characterized by hyperglycemia. Orally administered antidiabetic drugs like glibenclamide, glipalamide, and metformin can partially lower blood sugar levels, but long-term use causes kidney and liver damage. Recent breakthroughs in nanotheranostics have emerged as a powerful tool for diabetes treatment and diagnosis.

RESULTS

Nanotheranostics is a rapidly developing area that can revolutionize diabetes diagnosis and treatment by combining therapy and imaging in a single probe, allowing for pancreas-specific drug and insulin delivery. Nanotheranostic in Diabetes research has facilitated the development of improved glucose monitoring and insulin administration modalities, which promise to improve the quality of life for people with Diabetes drastically. Further, nanomaterials like nanocarriers and unique functional nanomaterials used as nano theranostics tools for treating Diabetes will also be highlighted.

CONCLUSION

The nanosensors discussed in this review article will encourage researchers to develop innovative nanomaterials with novel functionalities and properties for diabetes detection and treatment.

摘要

目的

本研究的目的是探讨纳米材料如纳米传感器在糖尿病诊断中的应用,并突出其在糖尿病治疗中的应用。

方法

糖尿病(D.M.)是一组以高血糖为特征的代谢性疾病。口服抗糖尿病药物如格列本脲、格列吡酰胺和二甲双胍可部分降低血糖水平,但长期使用会导致肾和肝损伤。纳米诊疗学的最新突破已成为糖尿病治疗和诊断的有力工具。

结果

纳米诊疗学是一个快速发展的领域,它可以通过将治疗和成像结合在一个探针中,彻底改变糖尿病的诊断和治疗,实现胰腺特异性药物和胰岛素递送。糖尿病研究中的纳米诊疗学促进了改进的血糖监测和胰岛素给药方式的发展,有望大幅提高糖尿病患者的生活质量。此外,还将重点介绍用作治疗糖尿病的纳米诊疗工具的纳米载体等纳米材料和独特的功能性纳米材料。

结论

本文中讨论的纳米传感器将鼓励研究人员开发具有新颖功能和特性的创新纳米材料,用于糖尿病检测和治疗。

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Nanotheranostics: application of nanosensors in diabetes management.纳米诊疗学:纳米传感器在糖尿病管理中的应用
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