Sikorski Bartosz L
Department of Ophthalmology, Nicolaus Copernicus University, 9 M. Sklodowskiej-Curie Street, Bydgoszcz 85-309, Poland.
Oculomedica Eye Research and Development Centre, Ogrody 14 Street, Bydgoszcz 85-870, Poland.
J Ophthalmol. 2022 Apr 21;2022:7339306. doi: 10.1155/2022/7339306. eCollection 2022.
To evaluate the performance of corneal epithelial thickness mapping (ETM) and demonstrate simultaneous measurement of ETMs and corneal topography using REVO NX (Optopol Technology, Zawiercie, Poland)-an OCT device for anterior and posterior segment imaging.
One hundred thirty-seven eyes of 137 normal subjects and patients with corneal diseases were recruited to the study. Each subject was scanned with REVO NX. ETMs and corneal topography maps were reconstructed from a single measurement. Corneal topography was also carried out using Pentacam (Oculus, Wetzlar, Germany). One hundred twenty-eight eyes were qualified for the final analysis. Forty healthy eyes were used to evaluate the performance of ETM, and 88 eyes were used to compare ETMs and corneal topography. The repeatability and reproducibility of ETMs in healthy subjects were assessed on the basis of 17 spatial zones derived from an 8-mm diameter corneal scan using within-subject standard deviation, test-retest repeatability, within-subject coefficient of variation (CoV), and intraclass correlation coefficient (ICC).
The ICC for both repeatability and reproducibility of ETMs for the central sector was 0.95. The ICC value for the other sectors was only moderately lower. However, the CoV for repeatability (≤1.55%) was slightly higher than the value reported for the RTVue device (Optovue, Inc, Fremont, California, USA), for which a CoV in the central zone of 1.07% was reported in unoperated eyes. The superior quadrants were found to be the thinnest while the inferior ones were the thickest. ETMs and topography maps created from a single OCT measurement present a complementary image of the cornea.
ETMs obtained using REVO NX show high levels of repeatability and reproducibility in normal eyes. Because the topographic and epithelial thickness analyses are performed using the same data, which means they are based on the exact same 3D corneal model, they do not require reciprocal centration and map matching. This ensures a complete point-to-point correlation between ETMs and corneal topography maps, which paints a fuller picture of a given pathology.
评估角膜上皮厚度测量图（ETM）的性能，并展示使用REVO NX（波兰扎维尔采Optopol Technology公司）同时测量ETM和角膜地形图，REVO NX是一款用于眼前节和眼后节成像的光学相干断层扫描（OCT）设备。
招募了137名正常受试者和角膜疾病患者的137只眼睛参与研究。每位受试者均使用REVO NX进行扫描。通过单次测量重建ETM和角膜地形图。还使用Pentacam（德国韦茨拉尔Oculus公司）进行角膜地形图检查。128只眼睛符合最终分析要求。40只健康眼睛用于评估ETM的性能，88只眼睛用于比较ETM和角膜地形图。基于从直径8毫米的角膜扫描得出的17个空间区域，使用受试者内标准差、重测重复性、受试者内变异系数（CoV）和组内相关系数（ICC）评估健康受试者中ETM的重复性和再现性。
ETM中央区域重复性和再现性的ICC均为0.95。其他区域的ICC值仅略低。然而，重复性的CoV（≤1.55%）略高于RTVue设备（美国加利福尼亚州弗里蒙特Optovue公司）报告的值，未手术眼睛中央区域的CoV报告为1.07%。发现上方象限最薄，下方象限最厚。从单次OCT测量创建的ETM和地形图呈现出角膜的互补图像。
使用REVO NX获得的ETM在正常眼睛中显示出高度的重复性和再现性。由于地形和上皮厚度分析使用相同的数据，这意味着它们基于完全相同的三维角膜模型，因此不需要相互对中以及地图匹配。这确保了ETM和角膜地形图之间完全的点对点相关性，从而更全面地描绘给定的病变情况。
