After the initial study of different protocols in the synthesis of indeno[2',1':5,6]pyrido[2,3-]pyrimidines, herein, a new method is presented using cheaper and more accessible starting materials to produce high-efficiency products. In this protocol, the novel nanocatalyst is very effective in the progression of the reaction and increasing the efficiency. This green approach in aqueous media has several advantages as compared with other methods, such as easier work-up, very mild reaction conditions, reusability of the catalyst, and eco-friendliness. The products of this four-component condensation were evaluated using IR, H NMR, C NMR spectra, and C. H. N. analyses, and the catalyst structure was confirmed by FT-IR, XRD, SEM, EDX, TGA and VSM techniques.