Ladiges Warren
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Aging Pathobiol Ther. 2022;4(1):23-24. doi: 10.31491/APT.2022.03.078. Epub 2022 Mar 30.
The geropathology concept assumes all age-related lesions are relevant, which allows the ability to grade each lesion in an organ with a severity score resulting in a quantitative value. Because aging pet cats have similar age-related diseases as older humans, knowledge of histopathology occurring during aging would be invaluable to determine how age-related lesions progress with increasing age and the connection with comorbidities. The ability to use the severity of specific organ geropathology to predict biological aging would provide new approaches to study pathways of aging and their role in the development of age-related diseases in animal models.
老年病理学概念假定所有与年龄相关的病变都是相关的，这使得能够用严重程度评分对器官中的每个病变进行分级，从而得出一个量化值。由于老年宠物猫与老年人患有相似的与年龄相关的疾病，了解衰老过程中发生的组织病理学对于确定与年龄相关的病变如何随年龄增长而进展以及与合并症的关联将非常宝贵。利用特定器官老年病理学的严重程度来预测生物衰老的能力将为研究衰老途径及其在动物模型中与年龄相关疾病发展中的作用提供新方法。
