Yan Ruixue, Guo Hao, Yang Zeyun, Niu Wenting, Yan Yu, Ma Jianpeng, Wang Mingyue, Yang Wu
Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Mikrochim Acta. 2025 Jul 14;192(8):502. doi: 10.1007/s00604-025-07338-z.
A sensitive electrochemical sensor was constructed for tyrosine detection by collaborating a highly conductivity, excellent electrocatalysis and large surface of nitrogen-rich porous covalent organic framework in situ grown on three-dimensional conductive carboxylated multi-walled carbon nanotubes network and catalytic activity of triangular silver nanosheets. The prepared electrochemical sensing platform exhibited satisfactory results for detection of tyrosine with a wide linear range of 0.6-280 μM and a low detection limit of 0.017 μM, which were significantly superior to those of most existing electrochemical methods. At the same time, the developed sensor was successfully applied to the detection of tyrosine in real samples including human serum and urine and displayed high recoveries, good stability, reproducibility, and anti-interference ability. This study not only provides a novel sensing platform for tyrosine monitoring but also offers an innovative design concept for leveraging multifunctional nanocomposites in biosensing applications.
通过将原位生长在三维导电羧基化多壁碳纳米管网络上的高导电性、优异电催化性能和大表面积的富氮多孔共价有机框架与三角形银纳米片的催化活性相结合，构建了一种用于酪氨酸检测的灵敏电化学传感器。所制备的电化学传感平台在检测酪氨酸方面表现出令人满意的结果，线性范围宽达0.6 - 280 μM，检测限低至0.017 μM，显著优于大多数现有电化学方法。同时，所开发的传感器成功应用于包括人血清和尿液在内的实际样品中酪氨酸的检测，并显示出高回收率、良好的稳定性、重现性和抗干扰能力。本研究不仅为酪氨酸监测提供了一种新型传感平台，还为在生物传感应用中利用多功能纳米复合材料提供了一种创新的设计理念。
