Fleischhacker W W, Günther V, Barnas C, Lieder F, Miller C
Int Clin Psychopharmacol. 1986 Jul;1(3):210-5. doi: 10.1097/00004850-198607000-00003.
The following paper presents an investigation of the efficacy of piracetam in alcoholic organic mental disorder. A double-blind placebo-controlled study design was used to compare 2 dosages of the substance (2 X 3 g vs. 2 X 12 g). Cognitive function was assessed on days 0, 7, 14, 28, 42. Analysis of the results from 24 patients showed a clear-cut amelioration of cognitive functions in all 3 treatment groups. No difference could be demonstrated between the administration of placebo and the lower dose of piracetam. Patients on the higher dose showed an earlier improvement on one of the tests, but the final scores were similar in all three treatment groups.
以下论文介绍了对吡拉西坦治疗酒精性器质性精神障碍疗效的一项调查。采用双盲安慰剂对照研究设计，比较该药物的两种剂量（2×3克与2×12克）。在第0、7、14、28、42天评估认知功能。对24名患者的结果分析表明，所有3个治疗组的认知功能均有明显改善。安慰剂给药与低剂量吡拉西坦之间未显示出差异。接受高剂量治疗的患者在其中一项测试中改善较早，但所有三个治疗组的最终得分相似。
