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用吡拉西坦治疗酒精所致器质性精神障碍。

Treatment of alcohol organic mental disorder with piracetam.

作者信息

Barnas C, Miller C, Gunther V, Fleischhacker W W

机构信息

Dpt. of Psychiatry, Innsbruck University Clinics, Austria.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):729-37. doi: 10.1016/0278-5846(87)90007-8.

DOI:10.1016/0278-5846(87)90007-8
PMID:3326044
Abstract
  1. The paper presents an investigation of the efficiency of piracetam in alcohol organic mental disorder. 2. A double blind placebo controlled study design was used to compare two dosages of the substance (2 x 3g versus 2 x 12g). 3. The cognitive functions of the patients, especially short term memory and concentration, were assessed on the days 0, 7, 14, 28 and 42 using various psychological instruments. 4. An analysis of 39 patients showed an improvement of cognitive functions in all three groups. 5. Patients receiving drug treatment showed earlier responses than patients receiving placebo; differences between the three investigational groups were not statistically significant. 6. The results achieved make the effect of piracetam appear somewhat questionable.
摘要
  1. 本文介绍了对吡拉西坦治疗酒精所致器质性精神障碍疗效的一项研究。2. 采用双盲安慰剂对照研究设计,比较该药物的两种剂量(2×3克与2×12克)。3. 在第0、7、14、28和42天使用各种心理测量工具评估患者的认知功能,尤其是短期记忆和注意力。4. 对39名患者的分析显示,所有三组患者的认知功能均有改善。5. 接受药物治疗的患者比接受安慰剂的患者反应更早;三个研究组之间的差异无统计学意义。6. 所取得的结果使吡拉西坦的疗效显得有些可疑。

相似文献

1
Treatment of alcohol organic mental disorder with piracetam.用吡拉西坦治疗酒精所致器质性精神障碍。
Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):729-37. doi: 10.1016/0278-5846(87)90007-8.
2
Piracetam in alcoholic organic mental disorder: a placebo controlled study comparing two dosages.吡拉西坦治疗酒精所致器质性精神障碍:一项比较两种剂量的安慰剂对照研究。
Int Clin Psychopharmacol. 1986 Jul;1(3):210-5. doi: 10.1097/00004850-198607000-00003.
3
High versus low-dose piracetam in alcohol organic mental disorder: a placebo controlled study.高剂量与低剂量吡拉西坦治疗酒精所致器质性精神障碍的对照研究:一项安慰剂对照试验
Psychopharmacology (Berl). 1990;100(3):361-5. doi: 10.1007/BF02244607.
4
[Cognitive function in alcoholics in a double-blind study of piracetam].[在一项关于吡拉西坦的双盲研究中酗酒者的认知功能]
Lijec Vjesn. 1990 Mar-Apr;112(3-4):111-4.
5
[Clinical use of piracetam in chronic alcoholism and its complications predelirium and delirium].
Med Welt. 1976 Oct 1;27(40):1912-5.
6
A double-blind investigation of piracetam (nootropil) versus placebo in the memory of geriatric inpatients.
Psychopharmacol Bull. 1978 Jan;14(1):23-5.
7
Piracetam and chlormethiazole in acute alcohol withdrawal: a controlled clinical trial.吡拉西坦与氯美噻唑治疗急性酒精戒断:一项对照临床试验。
J Int Med Res. 1978;6(5):395-400. doi: 10.1177/030006057800600508.
8
[Effect of piracetam on the brain-organic psychosyndrome in cerebrovascular insufficiency. Results of a double-blind study in 40 cases].
Ther Ggw. 1977 Aug;116(8):1504-21.
9
A double blind investigation of piracetam (Nootropil) vs placebo in geriatric memory.吡拉西坦(脑复康)与安慰剂治疗老年记忆障碍的双盲研究。
Pharmakopsychiatr Neuropsychopharmakol. 1977 Mar;10(2):49-56. doi: 10.1055/s-0028-1094519.
10
The effect of piracetam on volunteers in a low-pressure tank.吡拉西坦对低压舱内志愿者的影响。
J Int Med Res. 1980;8(1):90-4. doi: 10.1177/030006058000800116.

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Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.认知增强剂的行为筛选:从无差别测试到有效测试:第一部分。
Psychopharmacology (Berl). 1992;107(2-3):144-59. doi: 10.1007/BF02245132.