Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Fly (Austin). 2022 Dec;16(1):152-176. doi: 10.1080/19336934.2022.2061834.
In multicellular organisms, endocrine factors such as hormones and cytokines regulate development and homoeostasis through communication between different organs. For understanding such interorgan communications through endocrine factors, the fruit fly serves as an excellent model system due to conservation of essential endocrine systems between flies and mammals and availability of powerful genetic tools. In and other insects, functions of neuropeptides or peptide hormones from the central nervous system have been extensively studied. However, a series of recent studies conducted in revealed that peptide hormones derived from peripheral tissues also play critical roles in regulating multiple biological processes, including growth, metabolism, reproduction, and behaviour. Here, we summarise recent advances in understanding target organs/tissues and functions of peripherally derived peptide hormones in and describe how these hormones contribute to various biological events through interorgan communications.
在多细胞生物中，内分泌因子如激素和细胞因子通过不同器官之间的通讯来调节发育和内稳态。为了通过内分泌因子理解这种器官间通讯，果蝇作为一个极好的模型系统，因为在果蝇和哺乳动物之间存在着重要的内分泌系统的保守性，并且有可用的强大遗传工具。在 和其他昆虫中，来自中枢神经系统的神经肽或肽激素的功能已经得到了广泛的研究。然而，在 中进行的一系列最近的研究表明，源自外周组织的肽激素也在调节包括生长、代谢、繁殖和行为在内的多种生物学过程中发挥关键作用。在这里，我们总结了最近在理解 和 中源自外周的肽激素的靶器官/组织和功能方面的进展，并描述了这些激素如何通过器官间通讯来促进各种生物学事件。
