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Ginsenoside Rb1 selectively improved keratinocyte functions in vitro without affecting tissue regeneration in zebrafish larvae tail regrowth.

作者信息

Shandilya Umesh K, Lamers Kristen, Zheng Yashi, Moran Nicole, Karrow Niel A

机构信息

Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.

出版信息

In Vitro Cell Dev Biol Anim. 2022 Apr;58(4):269-277. doi: 10.1007/s11626-022-00664-z. Epub 2022 May 2.

DOI:10.1007/s11626-022-00664-z
PMID:35501555
Abstract
摘要

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1
Ginsenoside Rb1 selectively improved keratinocyte functions in vitro without affecting tissue regeneration in zebrafish larvae tail regrowth.人参皂苷Rb1在体外选择性地改善角质形成细胞功能,而不影响斑马鱼幼体尾巴再生中的组织再生。
In Vitro Cell Dev Biol Anim. 2022 Apr;58(4):269-277. doi: 10.1007/s11626-022-00664-z. Epub 2022 May 2.
2
Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae.人参皂苷 Rg1 作为选择性糖皮质激素受体激动剂具有抗炎作用而不影响斑马鱼幼虫组织再生。
Cells. 2020 Apr 29;9(5):1107. doi: 10.3390/cells9051107.
3
Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet-induced cholesterol of zebrafish.人参皂苷Rb1与野生冬虫夏草和子囊菌的生物转化及其对斑马鱼饮食诱导胆固醇的抗高血脂作用。
J Food Biochem. 2020 Jun;44(6):e13192. doi: 10.1111/jfbc.13192. Epub 2020 Mar 23.
4
Ginsenoside Rb1 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair.人参皂苷Rb1通过诱导DNA修复来抑制紫外线辐射诱导的细胞凋亡。
Biol Pharm Bull. 2009 May;32(5):837-41. doi: 10.1248/bpb.32.837.
5
Red ginseng extract promotes the hair growth in cultured human hair follicles.红参提取物可促进体外培养的人毛囊的毛发生长。
J Med Food. 2015 Mar;18(3):354-62. doi: 10.1089/jmf.2013.3031. Epub 2014 Nov 14.
6
Protective properties of ginsenoside Rb1 against UV-B radiation-induced oxidative stress in human dermal keratinocytes.人参皂苷Rb1对紫外线B辐射诱导的人皮肤角质形成细胞氧化应激的保护作用。
Pharmazie. 2015 Jun;70(6):381-7.
7
Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism.人参皂苷Rb1通过鞘氨醇-1-磷酸依赖性机制增强角质形成细胞迁移。
J Med Food. 2018 Nov;21(11):1129-1136. doi: 10.1089/jmf.2018.4246. Epub 2018 Aug 27.
8
Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice.从红参根中分离出的人参皂苷对小鼠烧伤创面愈合的影响。
Br J Pharmacol. 2006 Jul;148(6):860-70. doi: 10.1038/sj.bjp.0706794. Epub 2006 Jun 12.
9
[Experimental study of proliferation of Schwann cells cultured with ginsenoside Rb1].[人参皂苷Rb1培养雪旺细胞增殖的实验研究]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 Jan;17(1):26-9.
10
Ginsenosides Rb₁ and Rd regulate proliferation of mature keratinocytes through induction of p63 expression in hair follicles.人参皂苷 Rb₁ 和 Rd 通过诱导毛囊中 p63 的表达来调节成熟角质形成细胞的增殖。
Phytother Res. 2013 Jul;27(7):1095-101. doi: 10.1002/ptr.4828. Epub 2012 Sep 25.

本文引用的文献

1
Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model.人参皂苷 Rb1 可改善癌症恶病质小鼠模型中的关键炎症细胞因子 TNF-α 和 IL-6。
BMC Complement Med Ther. 2020 Jan 15;20(1):11. doi: 10.1186/s12906-019-2797-9.
2
Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration.揭示斑马鱼器官的再生策略:关于心脏、小脑、鳍和视网膜再生的全面系统生物学研究
BMC Syst Biol. 2018 Mar 19;12(Suppl 2):29. doi: 10.1186/s12918-018-0544-3.
3
Ginsenoside-Rb1-Mediated Anti-angiogenesis via Regulating PEDF and miR-33a through the Activation of PPAR-γ Pathway.
人参皂苷-Rb1通过激活PPAR-γ通路调控PEDF和miR-33a介导抗血管生成作用
Front Pharmacol. 2017 Nov 13;8:783. doi: 10.3389/fphar.2017.00783. eCollection 2017.
4
TNF signaling and macrophages govern fin regeneration in zebrafish larvae.肿瘤坏死因子信号传导和巨噬细胞调控斑马鱼幼体的鳍再生。
Cell Death Dis. 2017 Aug 10;8(8):e2979. doi: 10.1038/cddis.2017.374.
5
Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells.人参皂苷Rh2和Rg3通过增加人白血病Jurkat细胞中的线粒体活性氧来抑制细胞增殖并诱导细胞凋亡。
Mol Med Rep. 2017 Jun;15(6):3591-3598. doi: 10.3892/mmr.2017.6459. Epub 2017 Apr 11.
6
Inhibition of multiple myeloma cell proliferation by ginsenoside Rg3 via reduction in the secretion of IGF-1.人参皂苷Rg3通过减少胰岛素样生长因子-1(IGF-1)的分泌来抑制多发性骨髓瘤细胞增殖。
Mol Med Rep. 2016 Sep;14(3):2222-30. doi: 10.3892/mmr.2016.5475. Epub 2016 Jul 7.
7
Macrophages in Tissue Repair, Regeneration, and Fibrosis.组织修复、再生和纤维化中的巨噬细胞
Immunity. 2016 Mar 15;44(3):450-462. doi: 10.1016/j.immuni.2016.02.015.
8
Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition.韩国红参(人参迈耶)的特性:历史、制备方法和化学成分。
J Ginseng Res. 2015 Oct;39(4):384-91. doi: 10.1016/j.jgr.2015.04.009. Epub 2015 May 11.
9
Effects of Panax ginseng extract on human dermal fibroblast proliferation and collagen synthesis.人参提取物对人皮肤成纤维细胞增殖和胶原蛋白合成的影响。
Int Wound J. 2016 Mar;13 Suppl 1(Suppl 1):42-6. doi: 10.1111/iwj.12530. Epub 2015 Oct 28.
10
Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.人参皂苷Rg3通过下调组蛋白去乙酰化酶3(HDAC3)和增加p53乙酰化来抑制黑色素瘤细胞增殖。
PLoS One. 2014 Dec 18;9(12):e115401. doi: 10.1371/journal.pone.0115401. eCollection 2014.