Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2022 Apr;172(6):681-685. doi: 10.1007/s10517-022-05456-9. Epub 2022 May 2.
The article presents the results of a pilot study of the diversity and metabolic potential of the gut microbiome in adolescents with various forms of functional bowel disorder. The participants were the patients of the Clinic of Research Center for Family Health and Human Reproduction Problems. Biological material was studied using metagenomic sequencing of V3-V4 variable regions of the 16S rRNA gene. We showed that the composition of the minor component of the intestinal microbiome in adolescents with functional bowel disorder differs from that in the healthy subjects (control). Different types of transit disturbances in functional bowel disorder also differ from each other. According to the metabolic potential, adolescents can be divided into two groups irrespective of the pathophysiological manifestations: for one group, a more intensive metabolism in amino acid and lipid biosynthesis pathways was predicted than for the other.
本文介绍了一项关于功能性肠病青少年肠道微生物组多样性和代谢潜能的初步研究结果。研究对象为家庭健康和人类生殖问题研究中心临床诊所的患者。生物材料采用 V3-V4 可变区 16S rRNA 基因的宏基因组测序进行研究。结果表明，功能性肠病青少年肠道微生物组的次要成分组成与健康受试者（对照组）不同。功能性肠病中的不同类型的转运障碍也各不相同。根据代谢潜能，可将青少年分为两组，而与病理生理表现无关：一组青少年的氨基酸和脂质生物合成途径的代谢更为活跃。
