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系统分析 STK10 在急性髓系白血病中的预后意义、功能富集和免疫影响。

Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.

机构信息

Department of Hematology, Xijing Hospital, Air Force Military Medical University, Xian, 710032, Shaanxi, People's Republic of China.

Institute of Hematology, Northwest University, Xian, 710069, Shaanxi, People's Republic of China.

出版信息

BMC Med Genomics. 2022 May 1;15(1):101. doi: 10.1186/s12920-022-01251-7.

DOI:10.1186/s12920-022-01251-7
PMID:35501867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9063138/
Abstract

BACKGROUND

Despite deeper understanding of the genetic landscape of acute myeloid leukemia (AML), the improvement of survival is still a great challenge. STK10 is overexpressed in several cancers with functions varying according to cancer types. But the functions of STK10 in AML has never been reported.

METHODS

We analyzed the expression, prognosis and potential functions of STK10 utilizing public web servers. Metascape and the String database were used for functional and protein-protein interaction analyses.

RESULTS

We found STK10 was enriched in blood & immune cells and overexpressed in AML. High STK10 expression was associated with poor overall survival, which was also identified in the subgroups of patients ≤ 60 years old and patients with non-high-risk cytogenetics. We demonstrated genes associated with STK10 were enriched in blood, spleen and bone marrow, influencing the immune function and biological process of AML. ITGB2 and ITGAM might directly interact with STK10 and were associated with poor prognosis. Besides, STK10 was associated with the infiltration of immune cells and immune checkpoints, like HLA-E, CD274 and GAL-9.

CONCLUSIONS

The present study was the original description of STK10 in AML and set the stage for developing STK10 as a new prognostic marker or therapeutic target for AML.

摘要

背景

尽管人们对急性髓系白血病（AML）的遗传特征有了更深入的了解，但生存状况的改善仍然是一个巨大的挑战。STK10 在多种癌症中过表达，其功能因癌症类型而异。然而，STK10 在 AML 中的功能尚未见报道。

方法

我们利用公共网络服务器分析了 STK10 的表达、预后和潜在功能。使用 Metascape 和 String 数据库进行功能和蛋白质-蛋白质相互作用分析。

结果

我们发现 STK10 在血液和免疫细胞中富集，并在 AML 中过表达。高表达 STK10 与总体生存率差相关，在年龄≤60 岁和非高危细胞遗传学的患者亚组中也得到了验证。我们证明与 STK10 相关的基因在血液、脾脏和骨髓中富集，影响 AML 的免疫功能和生物学过程。ITGB2 和 ITGAM 可能与 STK10 直接相互作用，并与预后不良相关。此外，STK10 与免疫细胞和免疫检查点的浸润有关，如 HLA-E、CD274 和 GAL-9。

结论

本研究首次描述了 STK10 在 AML 中的作用，为将 STK10 作为 AML 的新预后标志物或治疗靶点的开发奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/ba616966bf2a/12920_2022_1251_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/a3772d257dbb/12920_2022_1251_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/71b1b38df9a8/12920_2022_1251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/b5e7e00a79da/12920_2022_1251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/171067771b99/12920_2022_1251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/d243d5cca37f/12920_2022_1251_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/741d4e863813/12920_2022_1251_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/ba616966bf2a/12920_2022_1251_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/a3772d257dbb/12920_2022_1251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/d995b1cfca10/12920_2022_1251_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/71b1b38df9a8/12920_2022_1251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/b5e7e00a79da/12920_2022_1251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/171067771b99/12920_2022_1251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/d243d5cca37f/12920_2022_1251_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/741d4e863813/12920_2022_1251_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fbb/9063138/ba616966bf2a/12920_2022_1251_Fig8_HTML.jpg

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