西咪替丁治疗十二指肠溃疡。对照试验。
Cimetidine in duodenal ulcer. Controlled trial.
作者信息
Blackwood W S, Maudgal D P, Pickard R G, Lawrence D, Northfield T C
出版信息
Lancet. 1976 Jul 24;2(7978):174-6. doi: 10.1016/s0140-6736(76)92347-3.
As part of a double-blind controlled clinical trial of cimetidine (1.6 g daily) in patients with endoscopically proven duodenal ulcer, repeat endoscopy has been carried out in 24 patients after two and/or six weeks' treatment. At six weeks, 9 out of 11 patients on cimetidine and 3 out of 12 patients on placebo had healed (P less than 0.025). A separate open pilot trial in 23 patients has shown no difference in ulcer healing at six weeks between patients taking 0.8 and 1.6 g daily. A total of 32 different patients received cimetidine in the two trials, and ulcer healing was observed in 21 (66%) at six weeks. No patients showed evidence of bone-marrow toxicity. A small but significant rise in mean S.G.O.T., S.G.P.T., and serum-creatinine occurred in 13 patients on cimetidine 1.6 g daily, but not in 13 patients on 0.8 g daily.
作为一项西咪替丁（每日1.6克）治疗经内镜证实的十二指肠溃疡患者的双盲对照临床试验的一部分，在24例患者接受两周和/或六周治疗后进行了重复内镜检查。六周时，服用西咪替丁的11例患者中有9例愈合，服用安慰剂的12例患者中有3例愈合（P小于0.025）。一项针对23例患者的单独开放试验表明，每日服用0.8克和1.6克的患者在六周时溃疡愈合情况无差异。在这两项试验中共有32例不同患者接受了西咪替丁治疗，六周时观察到21例（66%）溃疡愈合。没有患者表现出骨髓毒性的证据。每日服用1.6克西咪替丁的13例患者中，平均谷草转氨酶、谷丙转氨酶和血清肌酐有小幅但显著升高，但每日服用0.8克的13例患者中未出现这种情况。
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