Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany.
PLoS One. 2022 May 3;17(5):e0268005. doi: 10.1371/journal.pone.0268005. eCollection 2022.
The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a porcine weight group, in which the arterial diameters most closely match human cerebral artery diameters, and thus optimize the porcine in-vivo model for neuroendovascular purposes. A group of 42 German Landrace swine (45-74 kg) was divided into four subgroups according to their weight. Angiographic images of the swine were used to determine the arterial diameter of the main branches of the subclavian artery: axillary artery, brachial artery, external thoracic artery, subscapular artery (at two different segments), suprascapular artery, caudal circumflex humeral artery, thoracodorsal artery, and circumflex scapular artery. The porcine arterial diameters were correlated with animal weight and compared to luminal diameters of human arteries which are commonly involved in stroke: internal carotid artery, basilar artery, vertebral artery, middle cerebral artery and M2 branches of the middle cerebral artery. Swine weight was positively correlated with porcine arterial diameter. The most conformity with human arterial diameters was found within the two heavier porcine groups (55-74 kg). We suggest the use of swine with a weight between 55-59.7 kg, as lighter animals show less similarity with human arterial diameters and heavier animals could cause more problems with manipulation and handling.
猪锁骨下动脉的分支常用于血管内卒中介入培训和研究。本研究旨在确定一个与人类大脑动脉直径最接近的猪体重组，从而优化神经血管内的猪活体模型。一组 42 头德国长白猪（45-74 公斤）根据体重分为四个亚组。使用猪的血管造影图像确定锁骨下动脉的主要分支的动脉直径：腋动脉、肱动脉、胸外动脉、肩胛下动脉（在两个不同节段）、肩胛上动脉、旋肱后动脉、胸背动脉和旋肩胛动脉。将猪的动脉直径与动物体重相关联，并与常见于卒中的人类动脉的管腔直径进行比较：颈内动脉、基底动脉、椎动脉、大脑中动脉和大脑中动脉 M2 分支。猪的体重与猪的动脉直径呈正相关。在两个较重的猪体重组中发现与人类动脉直径最一致（55-74 公斤）。我们建议使用体重在 55-59.7 公斤之间的猪，因为较轻的动物与人类动脉直径的相似性较小，而较重的动物在操作和处理方面可能会出现更多问题。
