Laboratory of Biomedicine Translational, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105 - Bairro Universitário CEP: 88806-000 Criciúma-SC, Brazil.
Laboratory of Evidence-based Practice, Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Mato Grosso do Sul, Brazil.
Nutr Res. 2022 Aug;104:1-9. doi: 10.1016/j.nutres.2022.03.009. Epub 2022 Mar 27.
Among the main consequences of polycystic ovary syndrome (PCOS) are menstrual dysfunction, infertility, hyperandrogenism, insulin resistance, and weight gain; in aggravated cases, it can become a risk factor for the development of metabolic syndrome and cardiovascular disease. We hypothesized that green tea can be an option to complement the treatment of PCOS. Thus, this systematic review aims to evaluate the effects of green tea supplementation in women with PCOS. We searched for randomized controlled trials (RCTs) that evaluated women with PCOS who received green tea compared with placebo in electronic databases: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Library, LILACS via BVS, and Web of Science using the terms: "polycystic ovary syndrome," "green tea," "Camellia sinensis," "epigallocatechin gallate." The outcomes listed in the study protocol were body weight, fasting insulin, body mass index, body fat percentage, daily caloric intake, waist circumference, hip circumference, and waist/hip ratio. Four double-blind RCTs were included, with a total of 169 women: 85 in the green tea group and 84 in the placebo group. We found a significantly lower body weight (kg) for green tea group (mean difference, -2.80; 95% confidence interval, -5.25 to -0.35; P = .03; I² = 0%; 4 studies, 169 participants, very low-quality evidence). Green tea has potential positive effects for the reduction of weight, and future studies will be needed to confirm the estimated effect size; we reasonably expect this to be an option of adjuvant treatment in PCOS clinical management. Registration number: CRD42021226296.
多囊卵巢综合征（PCOS）的主要后果包括月经功能障碍、不孕、高雄激素血症、胰岛素抵抗和体重增加；在病情加重的情况下，它可能成为代谢综合征和心血管疾病发展的危险因素。我们假设绿茶可以作为 PCOS 治疗的一种选择。因此，本系统评价旨在评估绿茶补充剂对 PCOS 患者的影响。我们在电子数据库中搜索了评估接受绿茶与安慰剂治疗的 PCOS 女性的随机对照试验（RCT）：MEDLINE 通过 PubMed、EMBASE 通过 Elsevier、Cochrane 图书馆、LILACS 通过 BVS 和 Web of Science 使用以下术语：“多囊卵巢综合征”、“绿茶”、“Camellia sinensis”、“表没食子儿茶素没食子酸酯”。研究方案中列出的结局是体重、空腹胰岛素、体重指数、体脂百分比、每日热量摄入、腰围、臀围和腰臀比。纳入了四项双盲 RCT，共 169 名女性：绿茶组 85 名，安慰剂组 84 名。我们发现绿茶组体重（kg）显著降低（平均差异，-2.80；95%置信区间，-5.25 至 -0.35；P=0.03；I²=0%；4 项研究，169 名参与者，极低质量证据）。绿茶对减轻体重有潜在的积极作用，需要进一步的研究来证实估计的效应大小；我们合理地预计这将是 PCOS 临床管理中辅助治疗的一种选择。注册号：CRD42021226296。
