Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
H. K. College of Pharmacy, Mumbai University, Pratiksha Nagar, Jogeshwari, West Mumbai 400102, India.
Int J Pharm. 2022 Jun 10;621:121790. doi: 10.1016/j.ijpharm.2022.121790. Epub 2022 May 2.
Biomimetic nanotechnology could serve as an advancement in the domain of drug delivery and diagnosis with the application of natural cell membrane or synthetically-derived membrane nanoparticles (NPs). These biomimetic NPs endow significant therapeutic and diagnostic efficacy by their unique properties, such as immune invasion and better targeting ability. Additionally, these NPs have a unique ability to retain the inherent properties of cell membrane and membrane's intrinsic functionalities, which helps them to exhibit superior therapeutic effects. In this review, we describe how these membrane-clocked NPs endow superior therapeutic effects by immune invasion; along with this, the development of membrane-coated NPs and their method of preparation and characterization has been clearly described in the manuscript. Moreover, Various developed membrane-coated NPs such as red blood cell membrane-coated NPs, white blood cells membrane-coated NPs, platelet membrane coated, cancer cell membrane coated, bacterial membrane vesicles and, mesenchymal stem cells membrane-coated NPs have been established in this manuscript. At last, the discussion on the role of membrane-coated NPs as theranostics, and notably, the literature that demonstrates the shreds of evidences of these NPs in targeting and neutralizing the SARS-CoV-2 virus have also been incorporated.
仿生纳米技术可以在药物输送和诊断领域取得进展，应用天然细胞膜或合成衍生的膜纳米颗粒 (NPs)。这些仿生 NPs 通过其独特的性质，如免疫入侵和更好的靶向能力，赋予了显著的治疗和诊断效果。此外，这些 NPs 具有独特的保留细胞膜固有性质和膜固有功能的能力，这有助于它们表现出更好的治疗效果。在这篇综述中，我们描述了这些膜时钟 NPs 如何通过免疫入侵赋予优越的治疗效果；此外，本文还清楚地描述了膜包被 NPs 的发展及其制备和表征方法。此外，在本文中还建立了各种已开发的膜包被 NPs，如红细胞膜包被 NPs、白细胞膜包被 NPs、血小板膜包被、癌细胞膜包被、细菌膜泡和间充质干细胞膜包被 NPs。最后，还讨论了膜包被 NPs 作为治疗诊断的作用，特别是本文纳入了证明这些 NPs 在靶向和中和 SARS-CoV-2 病毒方面的一些证据。
