Division of Pharmacology & Toxicology, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India.
Biotechnology Division, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India.
Environ Toxicol Pharmacol. 2022 Jul;93:103868. doi: 10.1016/j.etap.2022.103868. Epub 2022 Apr 30.
Abrin is a toxin from the seeds of Abrus precatorius. Abrin is considerably more toxic than ricin and a potent bio-warfare agent. The mechanism of abrin induced hepatotoxicity remains unclear. Silibinin has antioxidant, anti-inflammatory and hepatoprotective activities. But, its therapeutic potential in abrin toxicity is unknown. In view of these facts, the purpose of this study was to delineate the mechanisms and ameliorative role of silibinin against abrin induced hepatotoxicity. Parameters related to liver functions, oxidative stress, inflammation, Fas pathway and histopathology were evaluated in the liver of BALB/c mice after abrin exposure. Abrin intoxication resulted in hepatotoxicity, oxidative stress, inflammation, altered histopathology and increased Fas pathway signaling. Silibinin improves survival of abrin-exposed mice by decreasing serum liver enzymes and reinstating the antioxidant capacity. Silibinin also inhibits abrin-induced inflammation and Fas pathway. Present study for the first time demonstrates the hepatoprotective potential of silibinin against abrin toxicity.
相思豆毒素是相思豆种子中的一种毒素。相思豆毒素的毒性比蓖麻毒素大得多，是一种有效的生物战剂。相思豆毒素诱导肝毒性的确切机制尚不清楚。水飞蓟素具有抗氧化、抗炎和保肝作用。但是，其在相思豆毒素毒性中的治疗潜力尚不清楚。鉴于这些事实，本研究的目的是阐明水飞蓟素对相思豆毒素诱导的肝毒性的作用机制和改善作用。在暴露于相思豆毒素后，通过评估 BALB/c 小鼠肝脏中的肝功能相关参数、氧化应激、炎症、Fas 途径和组织病理学来评估其作用。相思豆毒素中毒导致肝毒性、氧化应激、炎症、组织病理学改变和 Fas 途径信号转导增加。水飞蓟素通过降低血清肝酶和恢复抗氧化能力来提高暴露于相思豆毒素的小鼠的存活率。水飞蓟素还抑制相思豆毒素诱导的炎症和 Fas 途径。本研究首次证明了水飞蓟素对相思豆毒素毒性的保肝潜力。
