[Effects of sydnonimines derivatives on the antithrombogenic activity of endothelial cells in culture].

The antithrombogenic activity of vessels walls is a result of still incompletely elucidated properties of the single layer of endothelial cells. These properties have been approached as a body designated endothelial cell antithrombogenic activity (ECATA). We report herein that, under experimental and acute pharmacologic conditions, molsidomine, but not its main metabolite SIN-1, can produce very marked stimulation of this ECATA. Prostacyclin does not seem to be involved in these phenomena. This property may, in part, explain in vivo the antiplatelet activity of molsidomine.