Berenger F P, Cano J P, Rolland P H
Pathol Biol (Paris). 1987 Feb;35(2 Pt 2):241-3.
The antithrombogenic activity of vessels walls is a result of still incompletely elucidated properties of the single layer of endothelial cells. These properties have been approached as a body designated endothelial cell antithrombogenic activity (ECATA). We report herein that, under experimental and acute pharmacologic conditions, molsidomine, but not its main metabolite SIN-1, can produce very marked stimulation of this ECATA. Prostacyclin does not seem to be involved in these phenomena. This property may, in part, explain in vivo the antiplatelet activity of molsidomine.
血管壁的抗血栓形成活性是单层内皮细胞某些特性的结果，这些特性尚未完全阐明。这些特性被视为一种整体现象，称为内皮细胞抗血栓形成活性（ECATA）。我们在此报告，在实验和急性药理条件下，莫西多明而非其主要代谢产物SIN-1可显著刺激这种ECATA。前列环素似乎与这些现象无关。这一特性可能在一定程度上解释了莫西多明在体内的抗血小板活性。
