单分子纳米孔传感在定量分析中的应用。
The application of single molecule nanopore sensing for quantitative analysis.
机构信息
School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, New South Wales 2052, Australia.
出版信息
Chem Soc Rev. 2022 May 23;51(10):3862-3885. doi: 10.1039/d1cs00988e.
Nanopore-based sensors typically work by monitoring transient pulses in conductance current-time traces as molecules translocate through the nanopore. The unique property of being able to monitor single molecules gives nanopore sensors the potential as quantitative sensors based on the counting of single molecules. This review provides an overview of the concepts and fabrication of nanopore sensors as well as nanopore sensing with a view toward using nanopore sensors for quantitative analysis. We first introduce the classification of nanopores and highlight their applications in molecular identification with some pioneering studies. The review then shifts focus to recent strategies to extend nanopore sensors to devices that can rapidly and accurately quantify the amount of an analyte of interest. Finally, future prospects are provided and briefly discussed. The aim of this review is to aid in understanding recent advances, challenges, and prospects for nanopore sensors for quantitative analysis.
基于纳米孔的传感器通常通过监测分子通过纳米孔迁移时电导电流时间迹线中的瞬态脉冲来工作。能够监测单个分子的独特特性使纳米孔传感器有可能成为基于单个分子计数的定量传感器。本综述概述了纳米孔传感器的概念和制造，以及纳米孔传感，以期将纳米孔传感器用于定量分析。我们首先介绍纳米孔的分类，并突出一些开创性研究在分子识别中的应用。然后，综述将重点转移到最近的策略上，这些策略将纳米孔传感器扩展到能够快速准确地定量分析感兴趣分析物的设备中。最后，提供并简要讨论了未来的前景。本综述的目的是帮助理解用于定量分析的纳米孔传感器的最新进展、挑战和前景。
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