School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, People's Republic of China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
J Mater Chem B. 2022 Jun 1;10(21):4040-4047. doi: 10.1039/d2tb00471b.
Both magnesium and lithium are able to stimulate osteogenic and angiogenic activities. In this study, lithium magnesium phosphate (LiMg(PO), LiMg(PO) and LiMg(PO)) biomaterials were synthesized by a solid-state reaction method, and their bioceramic blocks and scaffolds were fabricated by compression molding and 3D printing, respectively. The results indicated that the lithium magnesium phosphates consisted of the Mg(PO) phase and/or LiMgPO phase. Compared with the lithium-free Mg(PO) bioceramics, the lithium magnesium phosphate bioceramics showed a lower porosity and consequently a higher compressive strength, and stimulated cellular proliferation, osteogenic differentiation and proangiogenic activity. results manifested that the LiMg(PO) bioceramic scaffolds efficiently promoted bone regeneration of critical-size calvarial defects in rats. Benefiting from the high compressive strength and capacity of stimulating osteogenesis and angiogenesis, the LiMg(PO) bioceramic scaffolds are considered promising for efficiently repairing the bone defects.
镁和锂都能刺激成骨和血管生成活性。在这项研究中，采用固态反应法合成了磷酸锂镁（LiMg(PO)、LiMg(PO) 和 LiMg(PO)）生物材料，并分别通过压缩成型和 3D 打印制备了其生物陶瓷块和支架。结果表明，锂镁磷酸盐由 Mg(PO)相和/或 LiMgPO 相组成。与不含锂的 Mg(PO)生物陶瓷相比，锂镁磷酸盐生物陶瓷的孔隙率较低，因此抗压强度较高，并能刺激细胞增殖、成骨分化和促血管生成活性。结果表明，LiMg(PO)生物陶瓷支架能有效促进大鼠临界尺寸颅骨缺损的骨再生。得益于高抗压强度和成骨和血管生成的能力，LiMg(PO)生物陶瓷支架被认为有望有效地修复骨缺损。
