Shenzhen Bay Laboratory, Shenzhen 518132, China.
Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China.
J Control Release. 2022 Jul;347:27-43. doi: 10.1016/j.jconrel.2022.04.046. Epub 2022 May 4.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Current pharmacological interventions for the CVDs suffer from low bioavailability, low retention rate, poor targeting, drug resistance complicated side effects. Extracellular vesicles (EVs), which are lipid vesicles secreted by cells, play key roles in pathological processes of CVDs. Engineered EVs and EV mimics with superior properties can overcome limitations of traditional medicine, thus emerging as alternative therapeutic options for the CVDs. In this Review, we summarized basic concepts of EVs and EV mimics, highlighted engineering strategies, and lastly discussed applications of engineered EVs and EV mimics against the CVDs. We believe this Review can provide some new insights on engineering EVs and EV mimics and facilitate their application in precise control of CVDs.
心血管疾病 (CVDs) 是全球范围内的主要死亡原因。目前针对 CVDs 的药物干预措施存在生物利用度低、保留率低、靶向性差、耐药性和复杂的副作用等问题。细胞分泌的脂质囊泡即细胞外囊泡 (EVs)，在 CVDs 的病理过程中发挥着关键作用。具有优越性能的工程化 EVs 和 EV 模拟物可以克服传统药物的局限性，因此成为 CVDs 的替代治疗选择。在这篇综述中，我们总结了 EVs 和 EV 模拟物的基本概念，强调了工程化策略，并讨论了针对 CVDs 的工程化 EVs 和 EV 模拟物的应用。我们相信，这篇综述可以为 EVs 和 EV 模拟物的工程化提供一些新的见解，并有助于它们在 CVDs 的精确控制中的应用。
