Nano Innovation Institute, Inner Mongolia Key Lab of Carbon Nanomaterials, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao, 028000, China.
Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, 75246, USA.
Macromol Biosci. 2023 Jul;23(7):e2200537. doi: 10.1002/mabi.202200537. Epub 2023 Mar 12.
Cell-based nanotherapy holds great potential to transform diagnosis and treatment patterns for human diseases, especially for cardiovascular diseases (CVDs). Surface coating with cell membrane has become a powerful strategy for functionalization of therapeutic nanoparticles to achieve biological performances of superior biocompatibility, immune evasion, and specificity. Additionally, extracellular vesicles (EVs) play key roles in the progression of CVDs with their ability of transferring cargos to distant tissues, thus emerging as an appealing option for the diagnosis and therapy of CVDs. In this review, recent progress in cell-based nanotherapy for CVDs is summarized, and different sources of EVs and biomimetic nanoplatforms derived from natural cells are highlighted. Meanwhile, their promising biomedical applications in the diagnosis and targeted treatment of different CVDs are also provided, followed by a discussion of their potential challenges and future prospects.
基于细胞的纳米治疗在改变人类疾病的诊断和治疗模式方面具有巨大潜力，特别是在心血管疾病 (CVDs) 方面。细胞膜的表面涂层已成为功能化治疗性纳米颗粒的强大策略，以实现卓越的生物相容性、免疫逃逸和特异性的生物学性能。此外，细胞外囊泡 (EVs) 具有向远处组织传递货物的能力，在 CVDs 的进展中发挥着关键作用，因此成为 CVDs 诊断和治疗的有吸引力的选择。在这篇综述中，总结了基于细胞的纳米治疗在 CVDs 方面的最新进展，并强调了不同来源的 EVs 和源自天然细胞的仿生纳米平台。同时，还提供了它们在不同 CVDs 的诊断和靶向治疗中的有前途的生物医学应用，并讨论了它们的潜在挑战和未来前景。
