首发重度抑郁症中的多指标结构协方差：一项图论分析。
Multimetric structural covariance in first-episode major depressive disorder: a graph theoretical analysis.
作者信息
Chen Chujun, Liu Zhening, Xi Chang, Tan Wenjian, Fan Zebin, Cheng Yixin, Yang Jun, Palaniyappan Lena, Yang Jie
机构信息
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan)
出版信息
J Psychiatry Neurosci. 2022 May 4;47(3):E176-E185. doi: 10.1503/jpn.210204. Print 2022 May-Jun.
BACKGROUND
Abnormalities of cortical morphology have been consistently reported in major depressive disorder (MDD), with widespread focal alterations in cortical thickness, surface area and gyrification. However, it is unclear whether these distributed focal changes disrupt the system-level architecture (topology) of brain morphology in MDD. If present, such a topological disruption might explain the mechanisms that underlie altered cortical morphology in MDD.
METHODS
Seventy-six patients with first-episode MDD (33 male, 43 female) and 66 healthy controls (32 male, 34 female) underwent structural MRI scans. We calculated cortical indices, including cortical thickness, surface area and local gyrification index, using FreeSurfer. We constructed morphological covariance networks using the 3 cortical indices separately, and we analyzed the topological properties of these group-level morphological covariance networks using graph theoretical approaches.
RESULTS
Topological differences between patients with first-episode MDD and healthy controls were restricted to the thickness-based network. We found a significant decrease in global efficiency but an increase in local efficiency of the left superior frontal gyrus and the right paracentral lobule in patients with first-episode MDD. When we simulated targeted lesions affecting the most highly connected nodes, the thickness-based networks in patients with first-episode MDD disintegrated more rapidly than those in healthy controls.
LIMITATIONS
Our sample of patients with first-episode MDD has limited generalizability to patients with chronic and recurrent MDD.
CONCLUSION
A systems-level disruption in cortical thickness (but not surface area or gyrification) occurs in patients with first-episode MDD.
背景
在重度抑郁症（MDD）中，皮质形态异常一直有报道，皮质厚度、表面积和脑回形成存在广泛的局灶性改变。然而，目前尚不清楚这些分布性局灶性变化是否会破坏MDD患者脑形态的系统级结构（拓扑结构）。如果存在这种拓扑结构破坏，可能会解释MDD中皮质形态改变的潜在机制。
方法
76例首发MDD患者（男33例，女43例）和66例健康对照者（男32例，女34例）接受了结构磁共振成像扫描。我们使用FreeSurfer计算皮质指数，包括皮质厚度、表面积和局部脑回形成指数。我们分别使用这3个皮质指数构建形态协方差网络，并使用图论方法分析这些组级形态协方差网络的拓扑特性。
结果
首发MDD患者与健康对照者之间的拓扑差异仅限于基于厚度的网络。我们发现首发MDD患者的全局效率显著降低，但左侧额上回和右侧中央旁小叶的局部效率增加。当我们模拟影响连接性最高节点的靶向损伤时，首发MDD患者基于厚度的网络比健康对照者的网络解体更快。
局限性
我们的首发MDD患者样本对慢性和复发性MDD患者的普遍适用性有限。
结论
首发MDD患者存在皮质厚度（而非表面积或脑回形成）的系统级破坏。
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