免疫细胞在急性肾损伤与修复中的作用
Role of Immune Cells in Acute Kidney Injury and Repair.
作者信息
Lee Sul A, Noel Sanjeev, Sadasivam Mohanraj, Hamad Abdel R A, Rabb Hamid
出版信息
Nephron. 2017;137(4):282-286. doi: 10.1159/000477181. Epub 2017 Jun 10.
Abstract
Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease.
摘要
急性肾损伤（AKI）在自体肾和移植肾中都是一个重大问题。在理解免疫细胞在急性肾损伤的早期损伤和修复过程中的作用方面已经取得了重大进展。在这篇简短的综述中，我们旨在更新关于各种免疫细胞在急性肾损伤中的病理生理影响的信息，特别强调修复方面。对急性肾损伤免疫病理学的更好理解将带来预防急性肾损伤、加速修复以及防止急性肾损伤进展为慢性肾病的新疗法。
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Kidney Int. 2017 Jul;92(1):154-164. doi: 10.1016/j.kint.2017.01.014. Epub 2017 Mar 17.
2
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Kidney Int. 2017 Jul;92(1):89-100. doi: 10.1016/j.kint.2017.01.009. Epub 2017 Mar 15.
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