Morizane Atsushi, Uehara Yoshio, Kitamura Satoko, Komori Masahiro, Matsushita Masahide, Takeuchi Seisho, Seo Hiromi
Department of General Medicine Kochi Medical School Hospital Nankoku Japan.
Department of Otolaryngology Kochi Medical School Nankoku Japan.
J Gen Fam Med. 2022 Mar 1;23(3):172-176. doi: 10.1002/jgf2.530. eCollection 2022 May.
One-third of the people in Japan are colonized with (.) and suffer from virulence factor-mediated subclinical inflammation of the nares. We investigated whether subclinical inflammation contributed to cedar pollinosis affecting 20 million people annually.
The study participants were 814 inhabitants of the A or B prefectures. We compared the colonization rate and population structure of ., in association with the prevalence of cedar pollinosis, between participants in these two areas.
A prefecture had twice the annual amount of airborne cedar pollen compared with B. The prevalence of cedar pollinosis was significantly higher in A (23.5%) than in B (13.1%) ( = 0.0004). Moreover, the prevalence of cedar pollinosis was higher in female participants (23.3%) than in male participants (14.7%) ( = 0.003). In addition, the prevalence of cedar pollinosis was higher in S. aureus carriers (24.2%) than in S. aureus noncarriers (17.9%) ( = 0.03). The isolation rate of clonal complex (CC) 508 was higher in the A group (21%) than in the B group (7%) ( = 0.015).
Nasal colonization of . is a major risk factor for cedar pollinosis. However, the direct mechanism of this risk is currently unknown.
日本三分之一的人感染了（此处原文缺失具体病菌名称），并患有由毒力因子介导的鼻腔亚临床炎症。我们调查了亚临床炎症是否会导致每年影响2000万人的雪松花粉症。
研究参与者为A或B县的814名居民。我们比较了这两个地区参与者中（具体病菌名称）的定植率和种群结构，并将其与雪松花粉症的患病率进行关联分析。
与B县相比，A县空气中雪松花粉的年含量是其两倍。A县雪松花粉症的患病率（23.5%）显著高于B县（13.1%）（P = 0.0004）。此外，女性参与者中雪松花粉症的患病率（23.3%）高于男性参与者（14.7%）（P = 0.003）。另外，金黄色葡萄球菌携带者中雪松花粉症的患病率（24.2%）高于非携带者（17.9%）（P = 0.03）。A组克隆复合体（CC）508的分离率（21%）高于B组（7%）（P = 0.015）。
（具体病菌名称）的鼻腔定植是雪松花粉症的主要危险因素。然而，目前尚不清楚这种风险的直接机制。
