Miao Longxing, Yang Yijun, Li Zhongwen, Fang Zengjun, Zhang Yongqing, Han Chun-Chao
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Pharmacy, Shandong Medical College, Jinan, China.
J Ginseng Res. 2022 Mar;46(2):206-213. doi: 10.1016/j.jgr.2021.11.007. Epub 2021 Nov 19.
Ginsenoside Rb2 is an active protopanaxadiol-type saponin, widely existing in the stem and leave of ginseng. Rb2 has recently been the focus of studies for pharmaceutical properties. This paper provides an overview of the preclinical and clinical pharmacokinetics for Rb2, which exhibit poor absorption, rapid tissue distribution and slow excretion through urine. Pharmacological studies indicate a beneficial role of Rb2 in the prevention and treatment of diabetes, obesity, tumor, photoaging, virus infection and cardiovascular problems. The underlying mechanism is involved in an inhibition of oxidative stress, ROS generation, inflammation and apoptosis via regulation of various cellular signaling pathways and molecules, including AKT/SHP, MAPK, EGFR/SOX2, TGF-β1/Smad, SIRT1, GPR120/AMPK/HO-1 and NF-κB. This work would provide a new insight into the understanding and application of Rb2. However, its therapeutic effects have not been clinically evaluated. Further studies should be aimed at the clinical treatment of Rb2.
人参皂苷Rb2是一种活性原人参二醇型皂苷，广泛存在于人参的茎和叶中。Rb2最近成为药物特性研究的焦点。本文概述了Rb2的临床前和临床药代动力学，其表现出吸收差、组织分布快和经尿液排泄缓慢的特点。药理研究表明Rb2在预防和治疗糖尿病、肥胖、肿瘤、光老化、病毒感染和心血管问题方面具有有益作用。其潜在机制涉及通过调节各种细胞信号通路和分子（包括AKT/SHP、MAPK、EGFR/SOX2、TGF-β1/Smad、SIRT1、GPR120/AMPK/HO-1和NF-κB）来抑制氧化应激、活性氧生成、炎症和细胞凋亡。这项工作将为Rb2的理解和应用提供新的见解。然而，其治疗效果尚未进行临床评估。进一步的研究应针对Rb2的临床治疗。
