Xiao Zhenyong, Yan Zhenxing, Sun Xiang, Zhu Zhiyuan, Wang Baoyan, Gao Mengqi, Lu Fengfei, Liu Jian, Zong Zhitao, Zhang Hongbo, Guo Yanwu
Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Department of Neurosurgery, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi, China.
Oxid Med Cell Longev. 2022 Apr 25;2022:9173514. doi: 10.1155/2022/9173514. eCollection 2022.
The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of -catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson's disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson's disease.
帕金森病的发病机制尚不清楚，目前尚无治愈帕金森病的方法。某些微小RNA（miRNA）的异常表达与帕金森病的发生和进展密切相关。在此，我们证明miR-9-5p通过调控直接靶向肿瘤抑制基因SCRIB的β-连环蛋白信号通路来抑制多巴胺能神经元凋亡。此外，miR-9-5p改善了帕金森病小鼠的运动功能。本研究结果表明，miR-9-5p可能是对抗帕金森病的一个潜在治疗靶点。
