Krieble B F, Rudy D W, Glick M R, Clayman M D
Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis.
Am J Med Sci. 1993 Jan;305(1):36-9. doi: 10.1097/00000441-199301000-00007.
Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.
一名新诊断为艾滋病的患者在接受高剂量静脉注射阿昔洛韦治疗播散性带状疱疹时出现了严重神经毒性和急性肾衰竭。血液透析使神经症状迅速缓解，并伴有血浆阿昔洛韦浓度降低。对于阿昔洛韦继发的严重神经毒性病例，尤其是伴有肾衰竭时，应考虑急性血液透析治疗。
