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病例报告:食指上出现钟乳石样溃疡。

Case Report: An Ulceration With a Stalactite Appearance on the Index Finger.

作者信息

Zhang Liangliang, Dai Yalan, Lin Mengting, Xu Qiuyun, Lin Tingting, Gong Ting, Cheng Bo, Ji Chao, Cai Donghua

机构信息

Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Department of Dermatology, Shishi Municipal General Hospital, Quanzhou, China.

出版信息

Front Med (Lausanne). 2022 Apr 18;9:801086. doi: 10.3389/fmed.2022.801086. eCollection 2022.

Abstract

, the most widespread species of all spp. bacteria, is proven to be one of the most universal pathogens in chronic wounds. In this case, a woman in her 40s consulted a physician about an asymptomatic ulceration with a stalactite appearance at the distal end of the index finger after she was exposed to a needle when vaccinating chickens. The patient did not response to ceftazidime. Physical examination revealed a well-demarcated violescent ulceration with a stalactite appearance at the distal end of the index finger. A biopsy of the lesion showed dense infiltration of multinucleated giant cells, histiocytes, and lymphocytes in the dermis. The result of metagenomics next-generation sequencing (NGS) showed 306 unique sequence reads of , covering 33.49% of the nucleotide sequences. The pathogen was identified as , which was resistant to ceftazidime. The patient was treated with ciprofloxacin hydrochloride and improved considerably. This case reported a distinctive cutaneous lesion of on human infection and showed a successful use of NGS in .

摘要

作为所有 spp. 细菌中分布最广泛的物种,已被证明是慢性伤口中最常见的病原体之一。在这个病例中,一名40多岁的女性在给鸡接种疫苗时被针头刺伤后,因食指末端出现无症状的钟乳石样溃疡而咨询医生。患者对头孢他啶无反应。体格检查发现食指末端有边界清晰的紫罗兰色溃疡,呈钟乳石样外观。病变活检显示真皮中有多核巨细胞、组织细胞和淋巴细胞的密集浸润。宏基因组学下一代测序(NGS)结果显示有306条独特的序列读数为 ,覆盖了33.49%的核苷酸序列。病原体被鉴定为 ,对头孢他啶耐药。患者接受盐酸环丙沙星治疗后有明显改善。该病例报告了 对人类感染的一种独特皮肤病变,并展示了NGS在 中的成功应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2383/9058116/c3bb9416e2c5/fmed-09-801086-g001.jpg

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