College of Food Science and Engineering, Ocean University of China, Qingdao, P. R. China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, P. R. China.
J Food Biochem. 2022 Aug;46(8):e14175. doi: 10.1111/jfbc.14175. Epub 2022 May 4.
Intestinal mucosal immunity is important to human body; however, obesity induced by high-fat diet may bring a series of problems, such as chronic inflammation which may damage intestinal mucosal immunity. In this study, the effects of two different enzymatic hydrolysates of porphyra on the function of intestinal mucosal were explored in obese mice. The results showed that 10 consecutive weeks of high-fat dietary intake resulted in weight gain and intestinal abnormalities in C57BL/6 mice. However, the administration of enzymatic hydrolysate of porphyra effectively protected the intestinal mucosa from these injuries while reducing levels of oxidative stress (MDA, GSH, and GSH-Px). Specifically, they were found to improve small intestine morphological structure, increase growth of goblet cells and mucous, raise expression levels of lysozyme, and stimulate SIgA secretion, especially in the group administered with the enzymatic hydrolysate containing protease and polysaccharide enzyme (EHPP). The results showed that the enzymatic hydrolysates of porphyra may provide a protective measure to maintain intestinal mucosal barriers, which is beneficial to overall health. Porphyra is widely distributed all over the world. Moreover, an increasing number of studies have described its diverse biological functions. Therefore, it is necessary to find a way to develop products related to porphyra. In this study, a new type of polysaccharide enzyme of porphyra found in our previous research was used to make a clear porphyra energy drink with a lower molecular weight polysaccharide. Our findings highlighted the repaired intestinal barriers in obese bodies after the treatment with the enzymatic hydrolysate. PRACTICAL APPLICATIONS: Porphyra is widely distributed all over the world. Moreover, an increasing number of studies have described its diverse biological functions. Therefore, it is necessary to find a way to develop products related to porphyra. In this study, a new type of polysaccharide enzyme of porphyra found in our previous research was used to make a clear porphyra energy drink with a lower molecular weight polysaccharide. Our findings highlighted the repaired intestinal barriers in obese bodies after the treatment with the enzymatic hydrolysate.
肠道黏膜免疫对人体很重要；然而，高脂肪饮食引起的肥胖可能会带来一系列问题，如慢性炎症，可能会损害肠道黏膜免疫。在这项研究中，我们探索了两种不同的紫菜酶解物对肥胖小鼠肠道黏膜功能的影响。结果表明，连续 10 周高脂肪饮食导致 C57BL/6 小鼠体重增加和肠道异常。然而，紫菜酶解物的给药有效地保护了肠道黏膜免受这些损伤，同时降低了氧化应激水平（MDA、GSH 和 GSH-Px）。具体来说，它们改善了小肠形态结构，增加了杯状细胞和粘液的生长，提高了溶菌酶的表达水平，并刺激了 SIgA 的分泌，尤其是在给予含有蛋白酶和多糖酶的紫菜酶解物（EHPP）的组中。结果表明，紫菜酶解物可能提供一种保护措施来维持肠道黏膜屏障，这对整体健康有益。紫菜在世界各地广泛分布。此外，越来越多的研究描述了它的多种生物学功能。因此，有必要找到一种方法来开发与紫菜相关的产品。在本研究中，我们使用了之前研究中发现的一种新型紫菜多糖酶来制作一种低分子量多糖的新型紫菜能量饮料。我们的研究结果强调了肥胖体在用酶解物治疗后修复的肠道屏障。
紫菜在世界各地广泛分布。此外，越来越多的研究描述了它的多种生物学功能。因此，有必要找到一种方法来开发与紫菜相关的产品。在本研究中，我们使用了之前研究中发现的一种新型紫菜多糖酶来制作一种低分子量多糖的新型紫菜能量饮料。我们的研究结果强调了肥胖体在用酶解物治疗后修复的肠道屏障。
