Medical Graduate, Jinnah Medical & Dental College, Karachi, Sindh, 74800, Pakistan.
Medical Student, Jinnah Sindh Medical University, Karachi, Sindh, 75510, Pakistan.
Neurodegener Dis Manag. 2022 Jun;12(3):155-164. doi: 10.2217/nmt-2022-0001. Epub 2022 May 5.
Parkinson's disease (PD) is a progressive neurological disorder that predominately affects dopaminergic neurons. We believe that this pooling of data will help to better understand the prodromal nature of depression in PD. We conducted this study in accordance with PRISMA guidelines 2020. Fifteen eligible articles were shortlisted for final analysis. Risk of bias assessment was also conducted The random-effect model revealed that the risk of subsequent PD in patients with prodromal depression was twice as likely (odds ratio, 2.04; 95% CI, 1.02-4.08) as compared with a healthy population. Our meta-analysis concluded that the subsequent risk of PD is significantly higher in patients with depression as compared with healthy individuals.
帕金森病（PD）是一种进行性神经障碍，主要影响多巴胺能神经元。我们相信，这些数据的汇集将有助于更好地理解 PD 中抑郁的前驱期性质。我们按照 PRISMA 指南 2020 进行了这项研究。有 15 篇符合条件的文章被选入最终分析。我们还进行了偏倚风险评估。随机效应模型显示，前驱期抑郁患者随后发生 PD 的风险是健康人群的两倍（优势比，2.04；95%置信区间，1.02-4.08）。我们的荟萃分析得出结论，与健康个体相比，患有抑郁症的患者随后发生 PD 的风险显著更高。
