School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Nat Prod Res. 2023 Feb;37(4):618-627. doi: 10.1080/14786419.2022.2065486. Epub 2022 May 5.
Fungal resistance to different therapeutic drugs has become a growing challenge. This crucial health problem requires new effective drug alternatives. Herein, we report the study of ' resin used in folk medicine as antimicrobial. Thus, ' resin was extracted with aqueous-ethanol and fractionated using Sephadex chromatography, furnishing its major compounds. The crude extracts and the isolated compounds were evaluated for their antimicrobial activity against bacteria and yeasts. The crude extract displayed MIC of 25 μg/mL against , and for and the MIC were between 2.9 and 5.9 μg/mL. The 7--Methyl-aromadendrin was the most effective against and (MIC = 1.6 μg/mL). 2--Galloyl-1,6--di---coumaroyl--D-glycopyranoside, first time reported, showed MIC of 3.1 μg/mL against and . Overall, this work gave promising results, indicating that ' resin and its compounds have the potential for developing anti-yeast products.
真菌对不同治疗药物的耐药性已成为一个日益严峻的挑战。这一关键的健康问题需要新的有效药物替代品。在此，我们报告了将“民间药用树脂用作抗微生物剂”的研究。为此，我们采用水-乙醇提取法提取“树脂”，并利用葡聚糖凝胶层析对其进行分离，得到其主要化合物。我们评估了粗提取物和分离得到的化合物对细菌和酵母菌的抗菌活性。粗提取物对 的 MIC 为 25μg/mL，而对 和 的 MIC 在 2.9 到 5.9μg/mL 之间。7--甲基-莪术呋喃醇对 和 （MIC = 1.6μg/mL）的抑制作用最为有效。首次报道的 2--没食子酰基-1,6--二--咖啡酰基--D-吡喃葡萄糖苷对 和 的 MIC 为 3.1μg/mL。总的来说，这项工作取得了有前景的结果，表明“树脂及其化合物具有开发抗真菌产品的潜力。”
