Department of Statistics, Rice University, Houston, Texas.
Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Biometrics. 2023 Jun;79(2):1226-1238. doi: 10.1111/biom.13684. Epub 2022 May 23.
This paper is motivated by studying differential brain activities to multiple experimental condition presentations in intracranial electroencephalography (iEEG) experiments. Contrasting effects of experimental conditions are often zero in most regions and nonzero in some local regions, yielding locally sparse functions. Such studies are essentially a function-on-scalar regression problem, with interest being focused not only on estimating nonparametric functions but also on recovering the function supports. We propose a weighted group bridge approach for simultaneous function estimation and support recovery in function-on-scalar mixed effect models, while accounting for heterogeneity present in functional data. We use B-splines to transform sparsity of functions to its sparse vector counterpart of increasing dimension, and propose a fast nonconvex optimization algorithm using nested alternative direction method of multipliers (ADMM) for estimation. Large sample properties are established. In particular, we show that the estimated coefficient functions are rate optimal in the minimax sense under the L norm and resemble a phase transition phenomenon. For support estimation, we derive a convergence rate under the norm that leads to a selection consistency property under δ-sparsity, and obtain a result under strict sparsity using a simple sufficient regularity condition. An adjusted extended Bayesian information criterion is proposed for parameter tuning. The developed method is illustrated through simulations and an application to a novel iEEG data set to study multisensory integration.
本文旨在研究颅内脑电图 (iEEG) 实验中对多种实验条件呈现的大脑活动差异。在大多数区域,实验条件的对比效果通常为零,而在一些局部区域则不为零,产生局部稀疏函数。此类研究本质上是一个函数到标量回归问题,不仅关注非参数函数的估计,还关注函数支持的恢复。我们提出了一种加权组桥方法,用于在函数到标量混合效应模型中同时进行函数估计和支持恢复,同时考虑到功能数据中的异质性。我们使用 B 样条将函数的稀疏性转换为其维数不断增加的稀疏向量对应物,并提出了一种使用嵌套交替方向乘子法 (ADMM) 的快速非凸优化算法进行估计。建立了大样本性质。特别是,我们证明了在 L 范数下,估计的系数函数在最小最大意义上是最优的,类似于相变现象。对于支持估计,我们推导出在范数下的收敛速度,这导致在 δ 稀疏性下的选择一致性性质,并使用简单的充分正则性条件在严格稀疏性下得到一个结果。提出了一种调整后的扩展贝叶斯信息准则用于参数调整。通过模拟和对一个新的 iEEG 数据集的应用,说明了所开发的方法,以研究多感觉整合。