Huang Yujun, Qu Hengxian, Liu Dong, Wa Yunchao, Sang Jian, Yin Boxin, Chen Dawei, Chen Xia, Gu Ruixia
College of Food Science and Technology, Yangzhou University Yangzhou Jiangsu 225127 China
Key Laboratory of Dairy Biotechnology and Safety Control Yangzhou Jiangsu 225127 China.
RSC Adv. 2020 Sep 16;10(57):34396-34402. doi: 10.1039/d0ra05694d.
A long-term high-fat diet (HFD) leads to significant oxidative stress in the body and induces inflammation. A preliminary evidence suggests a potential therapeutic utility of probiotics for this condition. To evaluate the potential effect of DALI02 on the oxidative stress and inflammatory damage induced by HFD, we used a hyperlipidemic rat as a model fed with HFD. Results revealed that HFD induced a significant oxidative stress and inflammation. However, results reveal that DALI02, manifested a significant decrease in levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and resistin, while the catalase (CAT), total antioxidant capability (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and adiponectin (ADPN) levels significantly increased. And it was dose-dependent that the effect of high dose groups with high viable count was particularly notable. The results suggest that DALI02 could alleviate oxidative stress and inflammation as it appeared to reduce lipid peroxidation and improved the lipid metabolism .
长期高脂饮食（HFD）会导致体内显著的氧化应激并引发炎症。初步证据表明益生菌对这种情况具有潜在的治疗作用。为了评估DALI02对高脂饮食诱导的氧化应激和炎症损伤的潜在影响，我们使用高脂血症大鼠作为喂食高脂饮食的模型。结果显示，高脂饮食诱导了显著的氧化应激和炎症。然而，结果表明，DALI02使丙二醛（MDA）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和抵抗素水平显著降低，而过氧化氢酶（CAT）、总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和脂联素（ADPN）水平显著升高。并且高活菌数高剂量组的效果尤为显著，呈剂量依赖性。结果表明，DALI02可以减轻氧化应激和炎症，因为它似乎减少了脂质过氧化并改善了脂质代谢。
