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在寻求抗氧化降解酰胺的过程中溶剂诱导的威廉姆森醚化选择性

Solvent-induced selectivity of Williamson etherification in the pursuit of amides resistant against oxidative degradation.

作者信息

Derr James B, Clark John A, Morales Maryann, Espinoza Eli M, Vadhin Sandra, Vullev Valentine I

机构信息

Department of Biochemistry, University of California Riverside CA 92521 USA

Department of Bioengineering, University of California Riverside CA 92521 USA.

出版信息

RSC Adv. 2020 Jun 25;10(41):24419-24424. doi: 10.1039/d0ra04465b. eCollection 2020 Jun 24.

DOI:10.1039/d0ra04465b
PMID:35516219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9055110/
Abstract

This article reports two discoveries. (1) 2-Methoxyethanol induces unprecedented selectivity for etherification of 5-hydroxy-2-nitrobenzic acids without forming undesired esters. (2) Such compounds are precursors for amides showing unusual robustness against oxidative degradation, essential for molecular electrets that transfer strongly oxidizing holes at about -6.4 eV vacuum.

摘要

本文报道了两项发现。（1）2-甲氧基乙醇对5-羟基-2-硝基苯甲酸的醚化反应具有前所未有的选择性，且不会形成不需要的酯。（2）这类化合物是酰胺的前体，对氧化降解表现出异常的稳定性，这对于在约-6.4 eV真空下转移强氧化性空穴的分子驻极体至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/8b3382a8d735/d0ra04465b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/c47853a603e5/d0ra04465b-c1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/39423550b439/d0ra04465b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/8838480dd5e4/d0ra04465b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/8b3382a8d735/d0ra04465b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/c47853a603e5/d0ra04465b-c1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/39423550b439/d0ra04465b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/8838480dd5e4/d0ra04465b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a105/9055110/8b3382a8d735/d0ra04465b-f2.jpg

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