在寻求抗氧化降解酰胺的过程中溶剂诱导的威廉姆森醚化选择性
Solvent-induced selectivity of Williamson etherification in the pursuit of amides resistant against oxidative degradation.
作者信息
Derr James B, Clark John A, Morales Maryann, Espinoza Eli M, Vadhin Sandra, Vullev Valentine I
机构信息
Department of Biochemistry, University of California Riverside CA 92521 USA
Department of Bioengineering, University of California Riverside CA 92521 USA.
出版信息
RSC Adv. 2020 Jun 25;10(41):24419-24424. doi: 10.1039/d0ra04465b. eCollection 2020 Jun 24.
This article reports two discoveries. (1) 2-Methoxyethanol induces unprecedented selectivity for etherification of 5-hydroxy-2-nitrobenzic acids without forming undesired esters. (2) Such compounds are precursors for amides showing unusual robustness against oxidative degradation, essential for molecular electrets that transfer strongly oxidizing holes at about -6.4 eV vacuum.
本文报道了两项发现。（1）2-甲氧基乙醇对5-羟基-2-硝基苯甲酸的醚化反应具有前所未有的选择性，且不会形成不需要的酯。（2）这类化合物是酰胺的前体，对氧化降解表现出异常的稳定性，这对于在约-6.4 eV真空下转移强氧化性空穴的分子驻极体至关重要。
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