Sohrabi Somayeh, Kassir Nour, Keshavarz Moraveji Mostafa
Department of Chemical Engineering, Amirkabir University of Technology, Tehran Polytechnic Iran
RSC Adv. 2020 Jul 23;10(46):27560-27574. doi: 10.1039/d0ra04566g. eCollection 2020 Jul 21.
Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of operations that can be rendered programmable and reconfigurable. This platform has dimensional scaling benefits that have enabled controlled and rapid mixing of fluids in the droplet reactors, resulting in decreased reaction times. This, coupled with the precise generation and repeatability of droplet operations, has made the droplet-based microfluidic system a potent high throughput platform for biomedical research and applications. In addition to being used as micro-reactors ranging from the nano- to femtoliter (10 liters) range; droplet-based systems have also been used to directly synthesize particles and encapsulate many biological entities for biomedicine and biotechnology applications. For this, in the following article we will focus on the various droplet operations, as well as the numerous applications of the system and its future in many advanced scientific fields. Due to advantages of droplet-based systems, this technology has the potential to offer solutions to today's biomedical engineering challenges for advanced diagnostics and therapeutics.
基于微滴的微流控系统已被证明可与许多化学和生物试剂兼容，并且能够执行各种可实现可编程和可重构的操作。该平台具有尺寸缩放优势，能够在微滴反应器中实现流体的可控快速混合，从而缩短反应时间。再加上微滴操作的精确生成和可重复性，基于微滴的微流控系统已成为生物医学研究和应用中强大的高通量平台。除了用作从纳升至飞升（10升）范围的微反应器外，基于微滴的系统还被用于直接合成颗粒，并封装用于生物医学和生物技术应用的许多生物实体。为此，在以下文章中，我们将重点关注各种微滴操作，以及该系统在许多先进科学领域的众多应用及其未来发展。由于基于微滴的系统具有优势，这项技术有潜力为当今生物医学工程在先进诊断和治疗方面的挑战提供解决方案。
