He Miao, Li Yang, Zhou Lijing, Li Yajun, Lei Ting, Yan Wei, Song Jiarui, Chen Li
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Radiology, Gaoping District People's Hospital, Nanchong, China.
Front Aging Neurosci. 2022 Apr 18;14:823535. doi: 10.3389/fnagi.2022.823535. eCollection 2022.
Patients with subcortical ischemic vascular disease (SIVD) suffer from memory disorders that are thought to be associated with the hippocampus. We aimed to explore changes in hippocampal subfields and the relationship between different hippocampal subfield volumes and different types of memory dysfunction in SIVD patients.
A total of 77 SIVD patients with cognitive impairment (SIVD-CI, = 39) or normal cognition (HC-SIVD, = 38) and 41 matched healthy controls (HCs) were included in this study. Memory function was measured in all subjects, and structural magnetic resonance imaging (MRI) was performed. Then, the hippocampus was segmented and measured by FreeSurfer 6.0 software. One-way ANOVA was used to compare the volume of hippocampal subfields among the three groups while controlling for age, sex, education and intracranial volume (ICV). Then, tests were used to evaluate differences between each pair of groups. Finally, correlations between significantly different hippocampal subfield volumes and memory scores were tested in SIVD patients.
Almost all hippocampal subfields were significantly different among the three groups except for the bilateral hippocampal fissure ( = 0.366, = 0.086, respectively.) and left parasubiculum ( = 0.166). Furthermore, the SIVD-CI patients showed smaller volumes in the right subiculum ( < 0.001), CA1 ( = 0.002), presubiculum ( = 0.002) and molecular layer of the hippocampus ( = 0.017) than the HC-SIVD patients. In addition, right subiculum volumes were positively related to Rey's Auditory Verbal Learning Test (RAVLT) word recognition ( = 0.230, = 0.050), reverse digit span test (R-DST) ( = 0.326, = 0.005) and Rey-Osterrieth Complex Figure Test (ROCF) immediate recall ( = 0.247, = 0.035) scores, right CA1 volumes were positively correlated with RAVLT word recognition ( = 0.261, = 0.026), and right presubiculum volumes showed positive relationships with R-DST ( = 0.254, = 0.030) and ROCF immediate recall ( = 0.242, = 0.039) scores.
SIVD might lead to general reductions in volume in multiple hippocampal subfields. However, SIVD-CI patients showed atrophy in specific subfields, which might be associated with memory deficits.
皮质下缺血性血管疾病（SIVD）患者存在记忆障碍，这种障碍被认为与海马体有关。我们旨在探讨SIVD患者海马亚区的变化以及不同海马亚区体积与不同类型记忆功能障碍之间的关系。
本研究共纳入77例有认知障碍的SIVD患者（SIVD-CI组，n = 39）或认知正常的SIVD患者（HC-SIVD组，n = 38）以及41名匹配的健康对照者（HCs）。对所有受试者进行记忆功能测量，并进行结构磁共振成像（MRI）检查。然后，使用FreeSurfer 6.0软件对海马体进行分割和测量。在控制年龄、性别、教育程度和颅内体积（ICV）的情况下，采用单因素方差分析比较三组之间海马亚区的体积。然后，使用t检验评估每两组之间的差异。最后，在SIVD患者中测试显著不同的海马亚区体积与记忆分数之间的相关性。
除双侧海马裂（p分别为0.366和0.086）和左侧副下托（p = 0.166）外，三组之间几乎所有海马亚区均存在显著差异。此外，SIVD-CI患者右侧下托（p < 0.001）、CA1（p = 0.002）、前下托（p = 0.002）和海马分子层（p = 0.017）的体积均小于HC-SIVD患者。此外，右侧下托体积与雷伊听觉词语学习测验（RAVLT）单词识别（r = 0.230，p = 0.050）、倒背数字广度测验（R-DST）（r = 0.326，p = 0.005）和雷伊复杂图形测验（ROCF）即时回忆（r = 0.247，p = 0.035）分数呈正相关，右侧CA1体积与RAVLT单词识别（r = 0.261，p = 0.026）呈正相关，右侧前下托体积与R-DST（r = 0.254，p = 0.030）和ROCF即时回忆（r = 0.242，p = 0.039）分数呈正相关。
SIVD可能导致多个海马亚区的体积普遍减小。然而，SIVD-CI患者在特定亚区出现萎缩，这可能与记忆缺陷有关。
