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聚砜膜的表面血液相容性改性——丙烯酸与磺化羟丙基壳聚糖的共价接枝

Surface hemocompatible modification of polysulfone membrane covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan.

作者信息

Tu Ming-Ming, Xu Jing-Jie, Qiu Yun-Ren

机构信息

College of Chemistry and Chemical Engineering, Central South University Changsha 410083 PR China

出版信息

RSC Adv. 2019 Feb 21;9(11):6254-6266. doi: 10.1039/c8ra10573a. eCollection 2019 Feb 18.

DOI:10.1039/c8ra10573a
PMID:35517280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9062722/
Abstract

In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel-Craft reaction between acrylic acid and the PSf membrane surface. Then, the modified SHPCS-AA-PSf membrane was prepared by grafting SHPCS onto the AA-PSf membrane surface the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the -COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm) compared with the pristine PSf membrane (341 μg cm). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.

摘要

在本研究中，将丙烯酸（AA）和磺化羟丙基壳聚糖（SHPCS）共价接枝到聚砜（PSf）膜表面以改善其血液相容性。首先，通过丙烯酸与PSf膜表面之间的傅克反应获得改性的AA-PSf膜。然后，通过将SHPCS接枝到AA-PSf膜表面，利用AA-PSf膜羧基与SHPCS氨基的脱水酰化反应制备改性的SHPCS-AA-PSf膜。衰减全反射傅里叶变换红外光谱（ATR-FTIR）和X射线光电子能谱（XPS）测量证实-COOH基团和SHPCS成功接枝到PSf膜表面。与原始PSf膜（341μg/cm）相比，改性PSf膜显示出抑制的血小板粘附和更低的蛋白质吸附（161μg/cm）。血液相容性测试表明，改性膜材料具有延长的凝血时间、血浆复钙时间（PRT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）和凝血酶原时间（PT）。所有这些结果表明，用丙烯酸和SHPCS对PSf膜进行表面改性具有良好的血液相容性和抗凝血性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a61/9062722/1dec34ff67b6/c8ra10573a-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a61/9062722/fd28391645c6/c8ra10573a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a61/9062722/1dec34ff67b6/c8ra10573a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a61/9062722/19cc8f116ef5/c8ra10573a-f1.jpg
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