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碘催化在温和条件下高效合成呫吨/噻吨-吲哚衍生物。

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions.

作者信息

Miao Weihang, Ye Pingting, Bai Mengjiao, Yang Zhixin, Duan Suyue, Duan Hengpan, Wang Xuequan

机构信息

Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, School of Science, Honghe University Mengzi Yunnan 661100 China

International Academy of Targeted Therapeutics and Innovation, School of Pharmacy, Chongqing University of Arts and Sciences Chongqing 402160 China.

出版信息

RSC Adv. 2020 Jul 2;10(42):25165-25169. doi: 10.1039/d0ra05217e. eCollection 2020 Jun 29.

DOI:10.1039/d0ra05217e
PMID:35517437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9055358/
Abstract

An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates.

摘要

已开发出一种碘催化的呫吨-9-醇和硫代呫吨-9-醇与吲哚的亲核取代反应，为高效合成产率良好至优异的呫吨/硫代呫吨-吲哚衍生物提供了一种方法。该方案具有几个优点，如反应时间短、绿色溶剂、操作简单、催化剂易于获得和反应条件温和。此外，该方法对官能团具有良好的耐受性，且底物范围广泛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/6012a10c63b6/d0ra05217e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/26a5c343640f/d0ra05217e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/f29518d148b5/d0ra05217e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/6012a10c63b6/d0ra05217e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/26a5c343640f/d0ra05217e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/f29518d148b5/d0ra05217e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b11/9055358/6012a10c63b6/d0ra05217e-s3.jpg

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Iodine-mediated synthesis of benzo[]fluorenones from yne-enones.碘介导的从烯炔酮合成苯并[]芴酮。
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